YF3A_SCHPO
ID YF3A_SCHPO Reviewed; 386 AA.
AC O13901;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10;
GN ORFNames=SPAC22A12.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAB16580.1; -; Genomic_DNA.
DR PIR; T38150; T38150.
DR RefSeq; NP_593240.1; NM_001018637.2.
DR AlphaFoldDB; O13901; -.
DR BioGRID; 278320; 2.
DR STRING; 4896.SPAC22A12.10.1; -.
DR SwissPalm; O13901; -.
DR MaxQB; O13901; -.
DR PaxDb; O13901; -.
DR EnsemblFungi; SPAC22A12.10.1; SPAC22A12.10.1:pep; SPAC22A12.10.
DR GeneID; 2541829; -.
DR KEGG; spo:SPAC22A12.10; -.
DR PomBase; SPAC22A12.10; -.
DR VEuPathDB; FungiDB:SPAC22A12.10; -.
DR eggNOG; KOG2877; Eukaryota.
DR HOGENOM; CLU_035066_5_0_1; -.
DR InParanoid; O13901; -.
DR OMA; FPYQNVL; -.
DR PhylomeDB; O13901; -.
DR Reactome; R-SPO-1483191; Synthesis of PC.
DR Reactome; R-SPO-1483213; Synthesis of PE.
DR PRO; PR:O13901; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004142; F:diacylglycerol cholinephosphotransferase activity; ISO:PomBase.
DR GO; GO:0004307; F:ethanolaminephosphotransferase activity; ISO:PomBase.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; ISO:PomBase.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; ISO:PomBase.
DR Gene3D; 1.20.120.1760; -; 1.
DR InterPro; IPR000462; CDP-OH_P_trans.
DR InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR InterPro; IPR014472; CHOPT.
DR PANTHER; PTHR10414; PTHR10414; 1.
DR Pfam; PF01066; CDP-OH_P_transf; 1.
DR PIRSF; PIRSF015665; CHOPT; 1.
DR PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..386
FT /note="Uncharacterized CDP-alcohol phosphatidyltransferase
FT class-I family protein C22A12.10"
FT /id="PRO_0000318106"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 386 AA; 44084 MW; 277B0A2E107AE8E7 CRC64;
MQLNRKQLKN LHNYKYSAID NSLLSKYILK PYWWNQLLKV IPMSMAPNLI TLIGLGFVVI
NILTMLVYKY HYEMDAFPSW VYASWAIGLF LYQSFDAIDG SQARRTGTSS PLGQLFDHGV
DAINTSFEVL LTIELLQLDM FSSILTQFAS LLYFYISTWE EYHTGTLYLS YFSGPVEGIV
MVIGLFALTA IKGDSFWLKL HPTPESWGFV RSFLPYYTYG SCLYNFMAFA LLLNVLQSLR
NALQAVQKNN GSVIKALSGI LPYFLQWMAV FSLYAKYPAF FEHHFLTIFC LNAFIFAYSV
GVVIVSHITE SPFPYWNVLI LPFLVDAVDA YTFGVLKNVQ TEYFFCYVGI CIGVYGNFVA
HVIAMITEEY GIKCLTIPSK PESKKN
