YF48_SCHPO
ID YF48_SCHPO Reviewed; 933 AA.
AC Q6LA54;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Uncharacterized WD repeat-containing protein C3H5.08c;
GN ORFNames=SPAC3H5.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-722, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB16599.2; -; Genomic_DNA.
DR PIR; T38754; T38754.
DR RefSeq; NP_594184.2; NM_001019608.2.
DR AlphaFoldDB; Q6LA54; -.
DR BioGRID; 280055; 39.
DR STRING; 4896.SPAC3H5.08c.1; -.
DR iPTMnet; Q6LA54; -.
DR MaxQB; Q6LA54; -.
DR PaxDb; Q6LA54; -.
DR PRIDE; Q6LA54; -.
DR EnsemblFungi; SPAC3H5.08c.1; SPAC3H5.08c.1:pep; SPAC3H5.08c.
DR GeneID; 2543641; -.
DR KEGG; spo:SPAC3H5.08c; -.
DR PomBase; SPAC3H5.08c; -.
DR VEuPathDB; FungiDB:SPAC3H5.08c; -.
DR eggNOG; KOG0283; Eukaryota.
DR HOGENOM; CLU_004759_2_0_1; -.
DR InParanoid; Q6LA54; -.
DR OMA; DCLCCFE; -.
DR PRO; PR:Q6LA54; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; HDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0006887; P:exocytosis; NAS:PomBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR040324; WDR44/Dgr2.
DR PANTHER; PTHR14221; PTHR14221; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..933
FT /note="Uncharacterized WD repeat-containing protein
FT C3H5.08c"
FT /id="PRO_0000316557"
FT REPEAT 314..353
FT /note="WD 1"
FT REPEAT 385..423
FT /note="WD 2"
FT REPEAT 425..465
FT /note="WD 3"
FT REPEAT 467..506
FT /note="WD 4"
FT REPEAT 517..563
FT /note="WD 5"
FT REPEAT 568..607
FT /note="WD 6"
FT REPEAT 617..657
FT /note="WD 7"
FT REPEAT 665..710
FT /note="WD 8"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 722
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 933 AA; 103688 MW; 6AB56486C097D65E CRC64;
MNGNLPHIQI QSPKNSLDHL NNGRQATHNF EHGKPGDREE ANGHADAHSS SGRSRYLSSD
TNLLRDGSSS LDPLSKHIMK RTRSEKTLSF LNPSRASSNT HLSREGTNRS SNVTRTVSGR
KSNHGSSLTD TGESDQLSLK SFGAIRQPSQ HRSSLFSRML GSTSHIFGIR EDMDNESSEE
ERDGIPRVEG NAADPFSWIP DGKNVWDSPP KYIRVLSHNK KEKSLDHLFL AQELYCKPTL
AATHDRYYEP RATDFPNLAH ESSEPSSSRH TADAQSITNA SVHLHNSSSP LNRTPSVISD
TLAVAITSNS SSNSSNNAIW AMKFSRDGRY LAVGGQDRIL RIWAVLDSEH ARSVASETCS
SDPNNPKLNL KAPVFSEAPI REYAGHTADI LDLSWSRNNF LLSSSMDKTA RLWHPVRKDC
LCCFEHSDFV TSIAFHPKDD RFFLSGSLDC KLRLWSIKEK AVSFWNELPE LITAVAFSPD
GGLAIAGTFV GLCLFYDTRG LRFRTQMSIR SSRGKNAKGS KVTGIQTRTQ MIDNIAGDTE
MLVTTNDSRI RIYNLRDKSL ELKFKGHANA QSQNRAYFDD DGNYVICGSE DHQVFIWDLP
PQHMHKTKKK KHEHFKASVR PITAAVFAPT KTKQLLTLSG DPVYLAAISA RRSSVISNAS
IETGPSLRNL KSLSHSYLPI EIMKGHIIVC GDLDGRIRVF RQDSVFAARK LIEKKNIERK
NSETLSNSSF FPQALKAHMN SISSPKRHFS LRHKKNASQI TNNENNGNDD IKKGDEPEEE
HVGLRKNSTQ EKNANLDPNE ALKRADMMML QEGASSMVYY SLTNLDNPGA TVNEAAKTAA
TIEQNEHEIQ TSVDPISNVK AILPNADDVS SKNSSTEDQL ECLRCGNSLF NVFSRSFVFE
GAKFSIVCSH CNRKLLKSGS DDGSETHEMS TLP
