YFAS1_SCHPO
ID YFAS1_SCHPO Reviewed; 189 AA.
AC Q9Y801; Q9UU25;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=FAS1 domain-containing protein mug57;
DE AltName: Full=Meiotically up-regulated gene 57 protein;
DE Flags: Precursor;
GN Name=mug57; ORFNames=SPBC146.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-156, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP FUNCTION IN SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in sporulation. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane; Peripheral membrane
CC protein. Note=Membrane-associated.
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DR EMBL; CU329671; CAB46763.2; -; Genomic_DNA.
DR EMBL; AB027857; BAA87161.1; ALT_SEQ; Genomic_DNA.
DR PIR; T39424; T39424.
DR RefSeq; NP_595399.2; NM_001021306.2.
DR AlphaFoldDB; Q9Y801; -.
DR SMR; Q9Y801; -.
DR BioGRID; 276632; 10.
DR STRING; 4896.SPBC146.10.1; -.
DR MaxQB; Q9Y801; -.
DR PaxDb; Q9Y801; -.
DR EnsemblFungi; SPBC146.10.1; SPBC146.10.1:pep; SPBC146.10.
DR GeneID; 2540094; -.
DR KEGG; spo:SPBC146.10; -.
DR PomBase; SPBC146.10; mug57.
DR VEuPathDB; FungiDB:SPBC146.10; -.
DR HOGENOM; CLU_1428769_0_0_1; -.
DR InParanoid; Q9Y801; -.
DR OMA; NGEMWIL; -.
DR PhylomeDB; Q9Y801; -.
DR PRO; PR:Q9Y801; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0009986; C:cell surface; ISM:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.30.180.10; -; 1.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR040200; Mug57-like.
DR PANTHER; PTHR28156; PTHR28156; 1.
DR Pfam; PF02469; Fasciclin; 1.
DR SUPFAM; SSF82153; SSF82153; 1.
DR PROSITE; PS50213; FAS1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Nucleus; Reference proteome; Signal; Sporulation.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..189
FT /note="FAS1 domain-containing protein mug57"
FT /id="PRO_0000008799"
FT DOMAIN 37..182
FT /note="FAS1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
SQ SEQUENCE 189 AA; 22138 MW; 092E8BB38E548AE2 CRC64;
MMKLFCLNIF RFLYTTSFIS AVLSFNQRPI NMQEVREPRL FELLAETRDC NIFSELIMQF
PDYVHLFQQK DQHITVLVPN DAAFQQCKVK PWAIEYKNGV AVKSTDIVHI TEQQAQDNIL
KFVERHIITS SPIEWNNEYK TIDGTDVHVI KKEEEIYINE SIHVLCRKKA SNGEMWVLNA
TLSTPSIRE
