ID   CBAR2_BOVIN             Reviewed;         288 AA.
AC   Q1RMK1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=CBY1-interacting BAR domain-containing protein 2;
DE   AltName: Full=Protein FAM92B;
GN   Name=CIBAR2; Synonyms=FAM92B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in ciliogenesis. In cooperation with CBY1 may
CC       facilitate ciliogenesis likely by the recruitment and fusion of
CC       endosomal vesicles at distal appendages during early stages of
CC       ciliogenesis. {ECO:0000250|UniProtKB:A1XBS5,
CC       ECO:0000250|UniProtKB:Q6ZTR7}.
CC   -!- SUBUNIT: Homodimer (via BAR-like domain). Heterodimer (via BAR-like
CC       domain) with FAM92A. Interacts with CBY1.
CC       {ECO:0000250|UniProtKB:Q6ZTR7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q6ZTR7}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6ZTR7}. Note=Extensive colocalization with CBY1
CC       at mother centrioles. {ECO:0000250|UniProtKB:Q6ZTR7}.
CC   -!- DOMAIN: The BAR-like domain displays limited similarity to other BAR
CC       domains. {ECO:0000250|UniProtKB:A1XBS5}.
CC   -!- SIMILARITY: Belongs to the CIBAR family. {ECO:0000305}.
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DR   EMBL; BC114851; AAI14852.1; -; mRNA.
DR   RefSeq; NP_001070602.1; NM_001077134.2.
DR   AlphaFoldDB; Q1RMK1; -.
DR   SMR; Q1RMK1; -.
DR   STRING; 9913.ENSBTAP00000027768; -.
DR   PaxDb; Q1RMK1; -.
DR   GeneID; 768078; -.
DR   KEGG; bta:768078; -.
DR   CTD; 339145; -.
DR   eggNOG; ENOG502QT9N; Eukaryota.
DR   HOGENOM; CLU_072172_2_0_1; -.
DR   InParanoid; Q1RMK1; -.
DR   OrthoDB; 1324464at2759; -.
DR   TreeFam; TF324316; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0035869; C:ciliary transition zone; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   CDD; cd07598; BAR_FAM92; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR035590; BAR_CBAR1/2.
DR   InterPro; IPR009602; CBAR/FAM92.
DR   PANTHER; PTHR21223; PTHR21223; 1.
DR   Pfam; PF06730; FAM92; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..288
FT                   /note="CBY1-interacting BAR domain-containing protein 2"
FT                   /id="PRO_0000333003"
FT   REGION          6..217
FT                   /note="BAR-like"
FT                   /evidence="ECO:0000250|UniProtKB:A1XBS5"
FT   REGION          133..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  33130 MW;  CBF309C5FD8CEA66 CRC64;
     MNIILSRDSQ VRVMEDTVTN AEKSFGQFCS LLAAYTRKTA RLRDKADQLV KQLIDFANTE
     NPEMRATLRN FAEDLAKVQD YRQAEVERLE TKVINPLKLY GVQIKQTRAE IKKFKSVRNN
     EIKQLEKLEK LRQKSPSDRQ TISQAETSVQ RASVDASRTS HQLEETVDTF QKQKLKDIQK
     IFSDFVTIEM VFHAKAVEVY SSAFQTLESY DLEKDLEDFR AKMHGVYGRY DARPPLMDTT
     LSPALPWSLA QSAQSTIRSQ RKEAVSEDDS AEEDPVEDLR GQAQRLNQ