CBAR2_MOUSE
ID CBAR2_MOUSE Reviewed; 292 AA.
AC Q3V2J0; B2RVK4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=CBY1-interacting BAR domain-containing protein 2;
DE AltName: Full=Protein FAM92B;
GN Name=Cibar2 {ECO:0000312|MGI:MGI:3588213};
GN Synonyms=Fam92b {ECO:0000312|MGI:MGI:3588213};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=27528616; DOI=10.1128/mcb.00160-16;
RA Li F.Q., Chen X., Fisher C., Siller S.S., Zelikman K., Kuriyama R.,
RA Takemaru K.I.;
RT "BAR domain-containing FAM92 proteins interact with chibby1 to facilitate
RT ciliogenesis.";
RL Mol. Cell. Biol. 36:2668-2680(2016).
CC -!- FUNCTION: May play a role in ciliogenesis. In cooperation with CBY1 may
CC facilitate ciliogenesis likely by the recruitment and fusion of
CC endosomal vesicles at distal appendages during early stages of
CC ciliogenesis. {ECO:0000250|UniProtKB:A1XBS5,
CC ECO:0000250|UniProtKB:Q6ZTR7}.
CC -!- SUBUNIT: Homodimer (via BAR-like domain). Heterodimer (via BAR-like
CC domain) with FAM92A. Interacts with CBY1.
CC {ECO:0000250|UniProtKB:Q6ZTR7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616}.
CC Note=Extensive colocalization with CBY1 at mother centrioles
CC (PubMed:27528616). {ECO:0000269|PubMed:27528616}.
CC -!- DOMAIN: The BAR-like domain displays limited similarity to other BAR
CC domains. {ECO:0000250|UniProtKB:A1XBS5}.
CC -!- SIMILARITY: Belongs to the CIBAR family. {ECO:0000305}.
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DR EMBL; AK131790; BAE20807.1; -; mRNA.
DR EMBL; AC163442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC147233; AAI47234.1; -; mRNA.
DR EMBL; BC147234; AAI47235.1; -; mRNA.
DR CCDS; CCDS22717.1; -.
DR RefSeq; NP_001029152.2; NM_001033980.2.
DR AlphaFoldDB; Q3V2J0; -.
DR SMR; Q3V2J0; -.
DR STRING; 10090.ENSMUSP00000038825; -.
DR iPTMnet; Q3V2J0; -.
DR PhosphoSitePlus; Q3V2J0; -.
DR MaxQB; Q3V2J0; -.
DR PaxDb; Q3V2J0; -.
DR PRIDE; Q3V2J0; -.
DR ProteomicsDB; 271850; -.
DR Antibodypedia; 44888; 29 antibodies from 13 providers.
DR Ensembl; ENSMUST00000048786; ENSMUSP00000038825; ENSMUSG00000042269.
DR GeneID; 436062; -.
DR KEGG; mmu:436062; -.
DR UCSC; uc033jic.1; mouse.
DR CTD; 339145; -.
DR MGI; MGI:3588213; Cibar2.
DR VEuPathDB; HostDB:ENSMUSG00000042269; -.
DR eggNOG; ENOG502QT9N; Eukaryota.
DR GeneTree; ENSGT00390000010285; -.
DR HOGENOM; CLU_072172_2_0_1; -.
DR InParanoid; Q3V2J0; -.
DR OMA; SDRQMIA; -.
DR OrthoDB; 1324464at2759; -.
DR PhylomeDB; Q3V2J0; -.
DR TreeFam; TF324316; -.
DR BioGRID-ORCS; 436062; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q3V2J0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q3V2J0; protein.
DR Bgee; ENSMUSG00000042269; Expressed in islet of Langerhans and 35 other tissues.
DR ExpressionAtlas; Q3V2J0; baseline and differential.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR CDD; cd07598; BAR_FAM92; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035590; BAR_CBAR1/2.
DR InterPro; IPR009602; CBAR/FAM92.
DR PANTHER; PTHR21223; PTHR21223; 1.
DR Pfam; PF06730; FAM92; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..292
FT /note="CBY1-interacting BAR domain-containing protein 2"
FT /id="PRO_0000333005"
FT REGION 6..217
FT /note="BAR-like"
FT /evidence="ECO:0000250|UniProtKB:A1XBS5"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 25
FT /note="F -> I (in Ref. 1; BAE20807)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 33274 MW; BC843D2047FDDEE9 CRC64;
MNVVLSRDSQ VRAMENTVTN AERYFGQFCS LLASYTRKTA RLRDKADQLV KQLIDFANTE
NPELRATIRD FAEDLAKVQD YRQAEVERLE AKVISPLKLY GAQIKQTRAD IKKCKRVQNN
EIKQLEKLEK LRQKSPSDRQ MISQAETSAQ RASVDTNRST LHLVETVDAF QEQKLKDLRR
IFSDFVTIEM VFHAKAVEVY SSAFQTLENY DLERDLQDFR AKTRGIYGHG EARPLTDTNP
APSVPWPLAS QSAQSTMARQ GKEAGGEEDS ETDSVEEIPL EDLKGQQQGP RD
