ID   YFCA_ECOL6              Reviewed;         269 AA.
AC   P0AD31; P14008;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Probable membrane transporter protein YfcA;
GN   Name=yfcA; OrderedLocusNames=c2873;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 4-toluene sulfonate uptake permease (TSUP)
CC       (TC 2.A.102) family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN81323.1; -; Genomic_DNA.
DR   RefSeq; WP_000447361.1; NC_004431.1.
DR   AlphaFoldDB; P0AD31; -.
DR   STRING; 199310.c2873; -.
DR   EnsemblBacteria; AAN81323; AAN81323; c2873.
DR   GeneID; 67416757; -.
DR   KEGG; ecc:c2873; -.
DR   eggNOG; COG0730; Bacteria.
DR   HOGENOM; CLU_045498_2_1_6; -.
DR   OMA; YAYGFIM; -.
DR   BioCyc; ECOL199310:C2873-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002781; TM_pro_TauE-like.
DR   Pfam; PF01925; TauE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..269
FT                   /note="Probable membrane transporter protein YfcA"
FT                   /id="PRO_0000169189"
FT   TOPO_DOM        1..7
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..84
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..111
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..156
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..197
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..269
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   269 AA;  28643 MW;  B640B0EBFF1BF7ED CRC64;
     METFNSLFMV SPLLLGVLFF VAMLAGFIDS IAGGGGLLTI PALMAAGMSP ANALATNKLQ
     ACGGSISATI YFIRRKVVSL SDQKLNIAMT FVGSMSGALL VQYVQADVLR QILPILVICI
     GLYFLLMPKL GEEDRQRRMY GLPFALIAGG CVGFYDGFFG PAAGSFYALA FVTLCGFNLA
     KATAHAKLLN ATSNIGGLLL FILGGKVIWA TGFVMLVGQF LGARMGSRLV LSKGQKLIRP
     MIVIVSAVMS AKLLYDSHGQ EILHWLGMN