YFCC_ECOLI
ID YFCC_ECOLI Reviewed; 506 AA.
AC P39263; P76493; P77678;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Putative basic amino acid antiporter YfcC;
GN Name=yfcC; OrderedLocusNames=b2298, JW2295;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-90.
RC STRAIN=K12 / KH131;
RX PubMed=7883769; DOI=10.1093/oxfordjournals.jbchem.a124616;
RA Kakuda H., Hosono K., Shiroishi K., Ichihara S.;
RT "Identification and characterization of the ackA (acetate kinase A)-pta
RT (phosphotransacetylase) operon and complementation analysis of acetate
RT utilization by an ackA-pta deletion mutant of Escherichia coli.";
RL J. Biochem. 116:916-922(1994).
RN [5]
RP IDENTIFICATION.
RA Rudd K.E.;
RL Unpublished observations (NOV-1994).
RN [6]
RP FUNCTION.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=24513124; DOI=10.1016/j.ab.2014.01.018;
RA Wang X., Xie Y., Gao P., Zhang S., Tan H., Yang F., Lian R., Tian J.,
RA Xu G.;
RT "A metabolomics-based method for studying the effect of yfcC gene in
RT Escherichia coli on metabolism.";
RL Anal. Biochem. 451:48-55(2014).
CC -!- FUNCTION: Metabolomic profiling of different yfcC over-expression and
CC deletion strains suggests that it may affect the glyoxylate shunt.
CC {ECO:0000305|PubMed:24513124}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: To H.influenzae HI_0594. {ECO:0000305}.
CC -!- SIMILARITY: To B.subtilis YcgA. {ECO:0000305}.
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DR EMBL; U00096; AAC75358.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16137.1; -; Genomic_DNA.
DR EMBL; D17576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; H65001; H65001.
DR RefSeq; NP_416801.2; NC_000913.3.
DR RefSeq; WP_001274493.1; NZ_STEB01000008.1.
DR AlphaFoldDB; P39263; -.
DR BioGRID; 4261493; 212.
DR DIP; DIP-11977N; -.
DR IntAct; P39263; 2.
DR STRING; 511145.b2298; -.
DR TCDB; 2.A.118.1.8; the basic amino acid antiporter (arcd) family.
DR PaxDb; P39263; -.
DR PRIDE; P39263; -.
DR EnsemblBacteria; AAC75358; AAC75358; b2298.
DR EnsemblBacteria; BAA16137; BAA16137; BAA16137.
DR GeneID; 946780; -.
DR KEGG; ecj:JW2295; -.
DR KEGG; eco:b2298; -.
DR PATRIC; fig|511145.12.peg.2393; -.
DR EchoBASE; EB2491; -.
DR eggNOG; COG1288; Bacteria.
DR HOGENOM; CLU_035307_0_0_6; -.
DR InParanoid; P39263; -.
DR OMA; GTRELKW; -.
DR PhylomeDB; P39263; -.
DR BioCyc; EcoCyc:G7190-MON; -.
DR PRO; PR:P39263; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018385; C4_dicarb_anaerob_car-like.
DR InterPro; IPR018387; YcgA/YfcC.
DR PANTHER; PTHR43652:SF6; PTHR43652:SF6; 1.
DR Pfam; PF03606; DcuC; 1.
PE 4: Predicted;
KW Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..506
FT /note="Putative basic amino acid antiporter YfcC"
FT /id="PRO_0000169191"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 1..34
FT /note="MSAITESKPTRRWAMPDTLVIIFFVAILTSLATW -> MLFNQPCHL (in
FT Ref. 4; D17576)"
FT /evidence="ECO:0000305"
FT CONFLICT 86..90
FT /note="GDERP -> AMNAR (in Ref. 4; D17576)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 54797 MW; FA9D2244C19971D5 CRC64;
MSAITESKPT RRWAMPDTLV IIFFVAILTS LATWVVPVGM FDSQEVQYQV DGQTKTRKVV
DPHSFRILTN EAGEPEYHRV QLFTTGDERP GLMNFPFEGL TSGSKYGTAV GIIMFMLVIG
GAFGIVMRTG TIDNGILALI RHTRGNEILF IPALFILFSL GGAVFGMGEE AVAFAIIIAP
LMVRLGYDSI TTVLVTYIAT QIGFASSWMN PFCVVVAQGI AGVPVLSGSG LRIVVWVIAT
LIGLIFTMVY ASRVKKNPLL SRVHESDRFF REKQADVEQR PFTFGDWLVL IVLTAVMVWV
IWGVIVNAWF IPEIASQFFT MGLVIGIIGV VFRLNGMTVN TMASSFTEGA RMMIAPALLV
GFAKGILLLV GNGEAGDASV LNTILNSIAN AISGLDNAVA AWFMLLFQAV FNFFVTSGSG
QAALTMPLLA PLGDLVGVNR QVTVLAFQFG DGFSHIIYPT SASLMATLGV CRVDFRNWLK
VGATLLGLLF IMSSVVVIGA QLMGYH
