ID   YFCO_ECOLI              Reviewed;         273 AA.
AC   P76498; Q2MAL7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized protein YfcO;
DE   Flags: Precursor;
GN   Name=yfcO; OrderedLocusNames=b2332, JW2329;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA   Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT   "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT   usher fimbriae with distinct surface specificities.";
RL   Environ. Microbiol. 12:1957-1977(2010).
CC   -!- FUNCTION: Part of the yfcOPQRSUV fimbrial operon. Could contribute to
CC       adhesion to various surfaces in specific environmental niches.
CC       Increases adhesion to eukaryotic T24 bladder epithelial cells in the
CC       absence of fim genes. {ECO:0000269|PubMed:20345943}.
CC   -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC       cAMP receptor protein (CRP)-mediated catabolite repression.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the operon under classical laboratory
CC       conditions does not result in any major effect on E.coli capacity to
CC       form biofilms compared with the wild-type strain.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC       conditions, but is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20345943}.
CC   -!- SIMILARITY: To S.typhimurium YadU. {ECO:0000305}.
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DR   EMBL; U00096; AAC75392.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76689.1; -; Genomic_DNA.
DR   PIR; B65006; B65006.
DR   RefSeq; NP_416835.2; NC_000913.3.
DR   RefSeq; WP_000698745.1; NZ_LN832404.1.
DR   AlphaFoldDB; P76498; -.
DR   BioGRID; 4260939; 10.
DR   STRING; 511145.b2332; -.
DR   PaxDb; P76498; -.
DR   PRIDE; P76498; -.
DR   EnsemblBacteria; AAC75392; AAC75392; b2332.
DR   EnsemblBacteria; BAE76689; BAE76689; BAE76689.
DR   GeneID; 946620; -.
DR   KEGG; ecj:JW2329; -.
DR   KEGG; eco:b2332; -.
DR   PATRIC; fig|511145.12.peg.2428; -.
DR   EchoBASE; EB3871; -.
DR   eggNOG; ENOG503064I; Bacteria.
DR   HOGENOM; CLU_095265_0_0_6; -.
DR   OMA; MMKIIRT; -.
DR   PhylomeDB; P76498; -.
DR   BioCyc; EcoCyc:G7203-MON; -.
DR   PHI-base; PHI:6598; -.
DR   PRO; PR:P76498; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR   InterPro; IPR021407; DUF2544.
DR   Pfam; PF11245; DUF2544; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..273
FT                   /note="Uncharacterized protein YfcO"
FT                   /id="PRO_0000013879"
SQ   SEQUENCE   273 AA;  30260 MW;  9D1D9C22959823DC CRC64;
     MKILRWLFAL VMLIATTEAM AAGHSVDVYY GYNGDSRNIA TFNLKIMMPS AVYVGEYKSS
     QWLMTGEILQ NVSWSGPPPA PSVKLIGYHQ NINKASCPGL PSGWNCGYYT FEVIVSAEIE
     SYFSCPWLVI MNDSEASPGG VTYQGPDSHD TICPSVSVQP YDVSWNENYV SKSKLLTLQS
     TGGVVEKTLS TYLMKDGKLC DSTQMNETGG YCRWVAQMIT FTASGCDKAE VSVTPNRHPI
     TDKQLHDMVV RVDTSSMQPI DSTCRFQYIL NEL