YFCR_ECOLI
ID YFCR_ECOLI Reviewed; 170 AA.
AC P76501; Q2MAL4;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized fimbrial-like protein YfcR;
DE Flags: Precursor;
GN Name=yfcR; OrderedLocusNames=b2335, JW2332;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT usher fimbriae with distinct surface specificities.";
RL Environ. Microbiol. 12:1957-1977(2010).
CC -!- FUNCTION: Part of the yfcOPQRSUV fimbrial operon. Could contribute to
CC adhesion to various surfaces in specific environmental niches.
CC Increases adhesion to eukaryotic T24 bladder epithelial cells in the
CC absence of fim genes. {ECO:0000269|PubMed:20345943}.
CC -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC cAMP receptor protein (CRP)-mediated catabolite repression.
CC {ECO:0000269|PubMed:20345943}.
CC -!- DISRUPTION PHENOTYPE: Deletion of the operon under classical laboratory
CC conditions does not result in any major effect on E.coli capacity to
CC form biofilms compared with the wild-type strain.
CC {ECO:0000269|PubMed:20345943}.
CC -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC conditions, but is functional when constitutively expressed.
CC {ECO:0000305|PubMed:20345943}.
CC -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U00096; AAC75395.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76692.1; -; Genomic_DNA.
DR PIR; E65006; E65006.
DR RefSeq; NP_416838.1; NC_000913.3.
DR RefSeq; WP_001311011.1; NZ_LN832404.1.
DR AlphaFoldDB; P76501; -.
DR SMR; P76501; -.
DR BioGRID; 4260531; 13.
DR BioGRID; 851159; 4.
DR IntAct; P76501; 4.
DR STRING; 511145.b2335; -.
DR PaxDb; P76501; -.
DR PRIDE; P76501; -.
DR DNASU; 946818; -.
DR EnsemblBacteria; AAC75395; AAC75395; b2335.
DR EnsemblBacteria; BAE76692; BAE76692; BAE76692.
DR GeneID; 946818; -.
DR KEGG; ecj:JW2332; -.
DR KEGG; eco:b2335; -.
DR PATRIC; fig|1411691.4.peg.4397; -.
DR EchoBASE; EB3874; -.
DR eggNOG; COG3539; Bacteria.
DR HOGENOM; CLU_114111_0_0_6; -.
DR OMA; FNASMTM; -.
DR PhylomeDB; P76501; -.
DR BioCyc; EcoCyc:G7206-MON; -.
DR PRO; PR:P76501; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009289; C:pilus; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IMP:EcoCyc.
DR GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IBA:GO_Central.
DR Gene3D; 2.60.40.1090; -; 1.
DR InterPro; IPR000259; Adhesion_dom_fimbrial.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR Pfam; PF00419; Fimbrial; 1.
DR SUPFAM; SSF49401; SSF49401; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..170
FT /note="Uncharacterized fimbrial-like protein YfcR"
FT /id="PRO_0000013773"
SQ SEQUENCE 170 AA; 17890 MW; 30CCDE3829E3FFDA CRC64;
MTGGVMSQKF VVGAGLLVCS VCSLSAMAGS KPVDLILRVL VDAPPPCSIK GSQVEFGNMI
ADNVDGTNYR QDAKYTLNCT NSLANDLRMQ LKGNTSTING ETVLSTNITG LGIRIENSAD
NSLFAVGENS WTPFNINNQP QLKAVPVKAS GAQLAAGEFN ASLTMVVDYQ
