ID   YFCV_ECOLI              Reviewed;         187 AA.
AC   P77288; P76940;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Uncharacterized fimbrial-like protein YfcV;
DE   Flags: Precursor;
GN   Name=yfcV; OrderedLocusNames=b2339, JW2336;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA   Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT   "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT   usher fimbriae with distinct surface specificities.";
RL   Environ. Microbiol. 12:1957-1977(2010).
CC   -!- FUNCTION: Part of the yfcOPQRSUV fimbrial operon. Could contribute to
CC       adhesion to various surfaces in specific environmental niches.
CC       Increases adhesion to eukaryotic T24 bladder epithelial cells in the
CC       absence of fim genes. {ECO:0000269|PubMed:20345943}.
CC   -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC       cAMP receptor protein (CRP)-mediated catabolite repression.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the operon under classical laboratory
CC       conditions does not result in any major effect on E.coli capacity to
CC       form biofilms compared with the wild-type strain.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC       conditions, but is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20345943}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U00096; AAC75399.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16193.1; -; Genomic_DNA.
DR   PIR; A65007; A65007.
DR   RefSeq; NP_416841.1; NC_000913.3.
DR   RefSeq; WP_000033316.1; NZ_LN832404.1.
DR   AlphaFoldDB; P77288; -.
DR   SMR; P77288; -.
DR   BioGRID; 4263168; 8.
DR   IntAct; P77288; 1.
DR   STRING; 511145.b2339; -.
DR   PaxDb; P77288; -.
DR   PRIDE; P77288; -.
DR   EnsemblBacteria; AAC75399; AAC75399; b2339.
DR   EnsemblBacteria; BAA16193; BAA16193; BAA16193.
DR   GeneID; 949109; -.
DR   KEGG; ecj:JW2336; -.
DR   KEGG; eco:b2339; -.
DR   PATRIC; fig|1411691.4.peg.4393; -.
DR   EchoBASE; EB3877; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_3_0_6; -.
DR   OMA; QDCNFNT; -.
DR   PhylomeDB; P77288; -.
DR   BioCyc; EcoCyc:G7210-MON; -.
DR   PRO; PR:P77288; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009289; C:pilus; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IMP:EcoCyc.
DR   GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IBA:GO_Central.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..187
FT                   /note="Uncharacterized fimbrial-like protein YfcV"
FT                   /id="PRO_0000013774"
SQ   SEQUENCE   187 AA;  19851 MW;  9BAE027695988940 CRC64;
     MSKFVKTAIA AAMVMGAFTS TATIAAGNNG TARFYGTIED SVCSIVPDDH KLEVDMGDIG
     AEKLKNNGTT TPKNFQIRLQ DCVFDTQETM TTTFTGTVSS ANSGNYYTIF NTDTGAAFNN
     VSLAIGDSLG TSYKSGMGID QKIVKDTATN KGKAKQTLNF KAWLVGAADA PDLGNFEANT
     TFQITYL