ID   CBBR_XANFL              Reviewed;         333 AA.
AC   P25545;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=HTH-type transcriptional regulator CbbR;
DE   AltName: Full=RuBisCO operon transcriptional regulator;
GN   Name=cbbR; Synonyms=cfxO;
OS   Xanthobacter flavus.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Xanthobacteraceae; Xanthobacter.
OX   NCBI_TaxID=281;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H4-14;
RX   PubMed=8407781; DOI=10.1128/jb.175.19.6097-6104.1993;
RA   van den Bergh E., Dijkhuizen L., Meijer W.G.;
RT   "CbbR, a LysR-type transcriptional activator, is required for expression of
RT   the autotrophic CO2 fixation enzymes of Xanthobacter flavus.";
RL   J. Bacteriol. 175:6097-6104(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-150.
RC   STRAIN=H4-14;
RX   PubMed=1900916; DOI=10.1007/bf00269865;
RA   Meijer W.G., Arnberg A.C., Enequist H.G., Terpstra P., Lidstrom M.E.,
RA   Dijkhuizen L.;
RT   "Identification and organization of carbon dioxide fixation genes in
RT   Xanthobacter flavus H4-14.";
RL   Mol. Gen. Genet. 225:320-330(1991).
CC   -!- FUNCTION: Transcriptional activator for the cbb operon (cbbLSXFP) for
CC       RuBisCO and other Calvin cycle genes. Binds specifically to two binding
CC       sites in the cbbR-cbbL intergenic region.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z22705; CAA80406.1; -; Genomic_DNA.
DR   EMBL; X17252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A36925; A36925.
DR   AlphaFoldDB; P25545; -.
DR   SMR; P25545; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..333
FT                   /note="HTH-type transcriptional regulator CbbR"
FT                   /id="PRO_0000105608"
FT   DOMAIN          5..62
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   333 AA;  36004 MW;  9B375B4FB2D1EE73 CRC64;
     MAPHWTLRQL RLVALAAASG SYAKAAQDMG LSPPAVTAQM KALEEDIGVP MFERVDGRLR
     PTAAGQELLS AQERIARALS EAERAIAALK SPERGSVVVG VVSTAKYFAP MALAAFRRRR
     PEIELRLIIG NREDIIRGIV SLDFDVAIMG RPPPALEAET RLIGDHPHIV VAPVDHPLFK
     RRKRITPADL TRESLLVREP GSGTRILMER VFEEAGAPNP PIAMEIGSNE TIKQSVMAGL
     GLAFISAHTV AAEVADGRLR VLEVEGLPVV RQWLAVRARD KRLLPAGQAL MDFLEREGAS
     FLPQMPGGEG GRCYLPDHVS GSTPAKAVAR DPV