YFE9_SCHPO
ID YFE9_SCHPO Reviewed; 631 AA.
AC O94443;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Uncharacterized exonuclease C637.09;
DE EC=3.1.-.-;
GN ORFNames=SPAC637.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR EMBL; CU329670; CAA22588.2; -; Genomic_DNA.
DR PIR; T39001; T39001.
DR RefSeq; NP_594627.2; NM_001020055.2.
DR AlphaFoldDB; O94443; -.
DR SMR; O94443; -.
DR BioGRID; 279923; 3.
DR STRING; 4896.SPAC637.09.1; -.
DR iPTMnet; O94443; -.
DR MaxQB; O94443; -.
DR PaxDb; O94443; -.
DR PRIDE; O94443; -.
DR EnsemblFungi; SPAC637.09.1; SPAC637.09.1:pep; SPAC637.09.
DR GeneID; 2543505; -.
DR KEGG; spo:SPAC637.09; -.
DR PomBase; SPAC637.09; -.
DR VEuPathDB; FungiDB:SPAC637.09; -.
DR eggNOG; KOG2248; Eukaryota.
DR HOGENOM; CLU_008679_1_0_1; -.
DR InParanoid; O94443; -.
DR OMA; HKAGPPF; -.
DR PRO; PR:O94443; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; ISO:PomBase.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:PomBase.
DR GO; GO:0034415; P:tRNA 3'-trailer cleavage, exonucleolytic; ISO:PomBase.
DR GO; GO:0034476; P:U5 snRNA 3'-end processing; ISO:PomBase.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1..631
FT /note="Uncharacterized exonuclease C637.09"
FT /id="PRO_0000317229"
FT DOMAIN 277..426
FT /note="Exonuclease"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 71471 MW; C6C34D432C455D1F CRC64;
MSKMGSSSMG ELQDGITQED SIEKKSKNVA SHGEKRKVKR KKEDLSMDGS NDGVKDSPDS
NDDSQSKKKK KKKLKKSQQP LNEENYPRLQ TTENNLQKPL KISDLQELVF WCLADGQAPS
WVLVRNKQMI HRAVILLVPG LEPSQFGFQP VRGNKHSFLL PNLLNENGPI QLPDFCEVFD
RAWPTRSPGD RFRVFSPVNA FLQSPLSNEQ KKKRDKETRA MASFSKPSDY LMSYESFIED
EYPLHPTVMK GEEVTQPSGW VASAGDFHSP PINPKILAID CEMVRTENGL EIARVTIVDM
KSEVIYDEFV KPESPVTDYV TQYSGITEEK LRNVTTVLSD VQSYLKKTVD NNTVLLGHSL
NSDLNCLKFT HPHIIDTANI YNHTRGPPSK PSLKWLATKW LRREIQKAGA LGHDSAEDAL
ACVDLLKLKV KNGPAFGLFN QDFESIFHRL SRQQPTPLIG AIADYGNPES CIGKAAHKSV
SCANDDEVVS AVVSLSDMHN FVWGRFRELE HAAMWNANRN TKQENNSDTD TENDSVEEDQ
VTSYSSALER FNRRIRLLYD SLPKGSLLLL YTGTGNPIEM SKLNAIRQQF RKEYQTKKWD
ELSVKWTDEE NMKYISAVEN TRNGLSFMTI K
