ID   YFEO_ECOUT              Reviewed;         418 AA.
AC   Q1R8X7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Putative ion-transport protein YfeO {ECO:0000255|HAMAP-Rule:MF_01115};
GN   Name=yfeO {ECO:0000255|HAMAP-Rule:MF_01115}; OrderedLocusNames=UTI89_C2721;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01115};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01115}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01115}.
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DR   EMBL; CP000243; ABE08187.1; -; Genomic_DNA.
DR   RefSeq; WP_000903099.1; NC_007946.1.
DR   AlphaFoldDB; Q1R8X7; -.
DR   SMR; Q1R8X7; -.
DR   EnsemblBacteria; ABE08187; ABE08187; UTI89_C2721.
DR   KEGG; eci:UTI89_C2721; -.
DR   HOGENOM; CLU_053130_0_0_6; -.
DR   OMA; WKVPGHA; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   HAMAP; MF_01115; CLC_YfeO; 1.
DR   InterPro; IPR022969; Chloride_channel_YfeO.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF81340; SSF81340; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..418
FT                   /note="Putative ion-transport protein YfeO"
FT                   /id="PRO_0000298430"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01115"
SQ   SEQUENCE   418 AA;  43664 MW;  15E748AB039F2B2C CRC64;
     MLHPRARTML LLSLPAVAIG IASSLILIMV MKIASVLQNL LWQRLPGTLG IAQDSPLWII
     GVLTLTGIAV GLVIRFSQGH AGPDPACEPL IGAPVPPSAL PGLIVALILG LAGGVSLGPE
     HPIMTVNIAL AVAIGARLLP RVNRMEWTIL ASAGTIGALF GTPVAAALIF SQTLNGSNEV
     PLWDRLFAPL MAAAAGALTT GLFFHPHFSL PIAHYGQMEM TDILSGAIVA AIAIAAGMVA
     VWCLPRLHAM MHQMKNPVFV LGIGGLILGI LGVIGGPVSL FKGLDEMQQM VANQAFSTSD
     YFLLAVIKLA ALVVAAASGF RGGRIFPAVF VGVALGLMLH EHVPAVPAAI TVSCAILGIV
     LVVTRDGWLS LFMAAVVVPN TTLLPLLCIV MLPAWLLLAG KPMMMVNRQK QQPPHDNV