CBCO1_HUMAN
ID CBCO1_HUMAN Reviewed; 208 AA.
AC Q8IVU9; Q5T1B8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Ciliary-associated calcium-binding coiled-coil protein 1 {ECO:0000312|HGNC:HGNC:28678};
GN Name=CABCOCO1 {ECO:0000312|HGNC:HGNC:28678};
GN Synonyms=C10orf107 {ECO:0000312|HGNC:HGNC:28678};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Calcium-binding protein. May be involved in the control of
CC sperm flagellar movement. {ECO:0000250|UniProtKB:Q8CDT7}.
CC -!- INTERACTION:
CC Q8IVU9; P42858: HTT; NbExp=3; IntAct=EBI-21771960, EBI-466029;
CC Q8IVU9; O14901: KLF11; NbExp=3; IntAct=EBI-21771960, EBI-948266;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CDT7}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q8CDT7}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q8CDT7}. Note=Colocalized with pericentrin at
CC centrosome of spermatocytes and round spermatids.
CC {ECO:0000250|UniProtKB:Q8CDT7}.
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DR EMBL; AC022398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL451049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041932; AAH41932.1; -; mRNA.
DR CCDS; CCDS7262.1; -.
DR RefSeq; NP_775825.1; NM_173554.2.
DR RefSeq; XP_005269657.1; XM_005269600.4.
DR AlphaFoldDB; Q8IVU9; -.
DR SMR; Q8IVU9; -.
DR BioGRID; 128558; 37.
DR IntAct; Q8IVU9; 6.
DR STRING; 9606.ENSP00000328698; -.
DR iPTMnet; Q8IVU9; -.
DR PhosphoSitePlus; Q8IVU9; -.
DR BioMuta; CABCOCO1; -.
DR DMDM; 71152994; -.
DR MassIVE; Q8IVU9; -.
DR PaxDb; Q8IVU9; -.
DR PeptideAtlas; Q8IVU9; -.
DR PRIDE; Q8IVU9; -.
DR ProteomicsDB; 70773; -.
DR Antibodypedia; 52377; 9 antibodies from 6 providers.
DR DNASU; 219621; -.
DR Ensembl; ENST00000330194.2; ENSP00000328698.2; ENSG00000183346.9.
DR GeneID; 219621; -.
DR KEGG; hsa:219621; -.
DR UCSC; uc010qik.3; human.
DR CTD; 219621; -.
DR DisGeNET; 219621; -.
DR GeneCards; CABCOCO1; -.
DR HGNC; HGNC:28678; CABCOCO1.
DR HPA; ENSG00000183346; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q8IVU9; -.
DR OpenTargets; ENSG00000183346; -.
DR PharmGKB; PA134897916; -.
DR VEuPathDB; HostDB:ENSG00000183346; -.
DR eggNOG; ENOG502RTDR; Eukaryota.
DR GeneTree; ENSGT00390000004181; -.
DR HOGENOM; CLU_078810_0_0_1; -.
DR InParanoid; Q8IVU9; -.
DR OrthoDB; 1422769at2759; -.
DR PhylomeDB; Q8IVU9; -.
DR TreeFam; TF329043; -.
DR PathwayCommons; Q8IVU9; -.
DR SignaLink; Q8IVU9; -.
DR BioGRID-ORCS; 219621; 13 hits in 1006 CRISPR screens.
DR ChiTaRS; CABCOCO1; human.
DR GenomeRNAi; 219621; -.
DR Pharos; Q8IVU9; Tdark.
DR PRO; PR:Q8IVU9; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8IVU9; protein.
DR Bgee; ENSG00000183346; Expressed in olfactory segment of nasal mucosa and 93 other tissues.
DR ExpressionAtlas; Q8IVU9; baseline and differential.
DR Genevisible; Q8IVU9; HS.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR InterPro; IPR032727; CLAMP.
DR PANTHER; PTHR28457; PTHR28457; 1.
DR Pfam; PF14769; CLAMP; 1.
PE 1: Evidence at protein level;
KW Calcium; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Metal-binding; Reference proteome.
FT CHAIN 1..208
FT /note="Ciliary-associated calcium-binding coiled-coil
FT protein 1"
FT /id="PRO_0000089819"
FT REGION 139..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 208 AA; 23883 MW; BA44BF4E2742753C CRC64;
MDFSIIQYSK FMTLLAMSLQ NLKTLHMSLE ESIKWLGEVM AEIGPTHSQK SEDWNIFDVK
QANAIIDYLK ISLFQHYKLY EFMFYSAREE IVIGTEQVIE VVKSACGPFP NPLEEGISFD
IYSTFIEPPT ILDTEMKRLD QEQGPEESQP ETDTSDMDPL VGFTIEDVKS VLDQVTDDIL
IGIQTEINEK LQIQEEAFNA RIEKLKKA
