CBCO1_MOUSE
ID CBCO1_MOUSE Reviewed; 208 AA.
AC Q8CDT7;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Ciliary-associated calcium-binding coiled-coil protein 1 {ECO:0000312|MGI:MGI:1920537};
GN Name=Cabcoco1 {ECO:0000312|MGI:MGI:1920537};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, CALCIUM-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=26990073; DOI=10.1002/mrd.22639;
RA Kawashima A., Kigoshi T., Katoh Y., Ishikawa Y., Shawki H.H., Inoue N.,
RA Tamba M., Matsuda M., Okamura N.;
RT "CABCOCO1, a novel coiled-coil protein with calcium-binding activity, is
RT localized in the sperm flagellum.";
RL Mol. Reprod. Dev. 83:912-926(2016).
CC -!- FUNCTION: Calcium-binding protein (PubMed:26990073). May be involved in
CC the control of sperm flagellar movement (PubMed:26990073).
CC {ECO:0000269|PubMed:26990073}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26990073}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:26990073}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:26990073}. Note=Colocalized with pericentrin at
CC centrosome of spermatocytes and round spermatids (PubMed:26990073).
CC {ECO:0000269|PubMed:26990073}.
CC -!- TISSUE SPECIFICITY: Testis-specific (PubMed:26990073). Expressed in
CC spermatocytes and round spermatids (at protein level)
CC (PubMed:26990073). {ECO:0000269|PubMed:26990073}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH87900.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC26533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK029622; BAC26533.1; ALT_INIT; mRNA.
DR EMBL; BC087900; AAH87900.1; ALT_INIT; mRNA.
DR RefSeq; NP_082767.1; NM_028491.1.
DR AlphaFoldDB; Q8CDT7; -.
DR SMR; Q8CDT7; -.
DR STRING; 10090.ENSMUSP00000020103; -.
DR PhosphoSitePlus; Q8CDT7; -.
DR PaxDb; Q8CDT7; -.
DR PRIDE; Q8CDT7; -.
DR ProteomicsDB; 265560; -.
DR Antibodypedia; 52377; 9 antibodies from 6 providers.
DR DNASU; 73287; -.
DR Ensembl; ENSMUST00000166919; ENSMUSP00000128895; ENSMUSG00000019945.
DR GeneID; 73287; -.
DR KEGG; mmu:73287; -.
DR UCSC; uc007fml.1; mouse.
DR CTD; 219621; -.
DR MGI; MGI:1920537; Cabcoco1.
DR VEuPathDB; HostDB:ENSMUSG00000019945; -.
DR eggNOG; ENOG502RTDR; Eukaryota.
DR GeneTree; ENSGT00390000004181; -.
DR InParanoid; Q8CDT7; -.
DR OrthoDB; 1422769at2759; -.
DR PhylomeDB; Q8CDT7; -.
DR TreeFam; TF329043; -.
DR BioGRID-ORCS; 73287; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Cabcoco1; mouse.
DR PRO; PR:Q8CDT7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CDT7; protein.
DR Bgee; ENSMUSG00000019945; Expressed in spermatocyte and 78 other tissues.
DR ExpressionAtlas; Q8CDT7; baseline and differential.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR InterPro; IPR032727; CLAMP.
DR PANTHER; PTHR28457; PTHR28457; 1.
DR Pfam; PF14769; CLAMP; 1.
PE 1: Evidence at protein level;
KW Calcium; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Metal-binding; Reference proteome.
FT CHAIN 1..208
FT /note="Ciliary-associated calcium-binding coiled-coil
FT protein 1"
FT /id="PRO_0000089820"
SQ SEQUENCE 208 AA; 24087 MW; 6C9D4CD8CBD3A5B3 CRC64;
MNFSIEQYSK FMTLLDMLLH NLQTLHMSLE DSIKWLGEVM AEIGPNHSQK SEDFHVFEVK
EANAIIDYLK ISLFQHYRLY EFLFYSTREE IVIGTEQTIE VVKPADYPFP APLEEGISLD
TYSTFIEPLP TPDMEQKVLD QEQGTQEALL ESEMREEDPL GGFTIDDVKS ALERVTDEVL
ISMQKEISEK LQVQEEAFNA RIEKLKKA
