ID   YFGM_NEIG1              Reviewed;         209 AA.
AC   O87406; Q5F9G9;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Ancillary SecYEG translocon subunit {ECO:0000250|UniProtKB:P76576};
DE   AltName: Full=ORF2;
DE   AltName: Full=Periplasmic chaperone YfgM {ECO:0000250|UniProtKB:P76576};
GN   OrderedLocusNames=NGO0425;
OS   Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=242231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10655208; DOI=10.1093/genetics/154.2.523;
RA   Mehr I.J., Long C.D., Serkin C.D., Seifert H.S.;
RT   "A homologue of the recombination-dependent growth gene, rdgC, is involved
RT   in gonococcal pilin antigenic variation.";
RL   Genetics 154:523-532(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700825 / FA 1090;
RA   Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F.,
RA   Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C.,
RA   Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H., Qi S.,
RA   Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.;
RT   "The complete genome sequence of Neisseria gonorrhoeae.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May mediate protein transfer from the SecYEG translocon to
CC       the periplasmic chaperone network via its periplasmic C-terminal
CC       region. {ECO:0000250|UniProtKB:P76576}.
CC   -!- SUBUNIT: Interacts with the SecYEG translocon (By similarity). Forms a
CC       complex with PpiD (By similarity). {ECO:0000250|UniProtKB:P76576}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P76576}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:P76576}; Periplasmic side
CC       {ECO:0000250|UniProtKB:P76576}.
CC   -!- SIMILARITY: Belongs to the YfgM family. {ECO:0000305}.
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DR   EMBL; AF058711; AAC63507.1; -; Genomic_DNA.
DR   EMBL; AE004969; AAW89168.1; -; Genomic_DNA.
DR   RefSeq; WP_003690875.1; NC_002946.2.
DR   RefSeq; YP_207580.1; NC_002946.2.
DR   AlphaFoldDB; O87406; -.
DR   SMR; O87406; -.
DR   STRING; 242231.NGO_0425; -.
DR   EnsemblBacteria; AAW89168; AAW89168; NGO_0425.
DR   GeneID; 66752764; -.
DR   KEGG; ngo:NGO_0425; -.
DR   PATRIC; fig|242231.10.peg.509; -.
DR   HOGENOM; CLU_084785_1_1_4; -.
DR   OMA; RFFANNG; -.
DR   Proteomes; UP000000535; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR018704; TPR_21.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR026039; YfgM.
DR   PANTHER; PTHR38035; PTHR38035; 1.
DR   Pfam; PF09976; TPR_21; 1.
DR   PIRSF; PIRSF006170; YfgM; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Chaperone; Membrane;
KW   Reference proteome; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="Ancillary SecYEG translocon subunit"
FT                   /id="PRO_0000214366"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P76576"
FT   TRANSMEM        24..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..209
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P76576"
FT   REPEAT          161..194
FT                   /note="TPR"
SQ   SEQUENCE   209 AA;  23149 MW;  032AD050FDE577FE CRC64;
     MAAHLEEQQE LDNFKYFWKT TGKWLFALLI LAALGYLGYT VYQNRAASQN QEAAAVLANI
     VEKAQNKAPQ SEINAELSKL QQSYPHSISA AQATLMAAAT EFDAQRYDVA EGHLKWVLSN
     QKDSLIQALA AQRLGVVLLQ QKKYDAALAA LDTPVEADFA PLLMETKGDV YAAQEKSQEA
     LKNYGQALEK MPQDSVGREL LQMKLDSLK