ID   YFHE_SCHPO              Reviewed;         398 AA.
AC   O42851; P78886;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Uncharacterized trans-sulfuration enzyme C23A1.14c;
GN   ORFNames=SPAC23A1.14c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-286.
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAA16988.1; -; Genomic_DNA.
DR   EMBL; D89237; BAA13898.1; -; mRNA.
DR   PIR; T38233; T38233.
DR   PIR; T43142; T43142.
DR   RefSeq; NP_594443.1; NM_001019872.2.
DR   AlphaFoldDB; O42851; -.
DR   SMR; O42851; -.
DR   BioGRID; 278523; 16.
DR   IntAct; O42851; 1.
DR   STRING; 4896.SPAC23A1.14c.1; -.
DR   iPTMnet; O42851; -.
DR   MaxQB; O42851; -.
DR   PaxDb; O42851; -.
DR   EnsemblFungi; SPAC23A1.14c.1; SPAC23A1.14c.1:pep; SPAC23A1.14c.
DR   GeneID; 2542042; -.
DR   KEGG; spo:SPAC23A1.14c; -.
DR   PomBase; SPAC23A1.14c; -.
DR   VEuPathDB; FungiDB:SPAC23A1.14c; -.
DR   eggNOG; KOG0053; Eukaryota.
DR   HOGENOM; CLU_018986_3_0_1; -.
DR   InParanoid; O42851; -.
DR   OMA; CYLTVDA; -.
DR   PhylomeDB; O42851; -.
DR   Reactome; R-SPO-1614558; Degradation of cysteine and homocysteine.
DR   Reactome; R-SPO-1614603; Cysteine formation from homocysteine.
DR   PRO; PR:O42851; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IBA:GO_Central.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   GO; GO:0016740; F:transferase activity; ISM:PomBase.
DR   GO; GO:0019346; P:transsulfuration; IBA:GO_Central.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808; PTHR11808; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   2: Evidence at transcript level;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..398
FT                   /note="Uncharacterized trans-sulfuration enzyme C23A1.14c"
FT                   /id="PRO_0000114765"
FT   MOD_RES         212
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        268
FT                   /note="K -> E (in Ref. 2; BAA13898)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        278
FT                   /note="Q -> L (in Ref. 2; BAA13898)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   398 AA;  43284 MW;  651C2BCEF59BCEA7 CRC64;
     MTHTPSFDLS DIKSTLSTNV LHADDAYALE NDVAPPIHIS TTYTYPGTPD TLQPFTKLAE
     EDFPYYARIS GNNVDRAEAS LSSVLGAPSV VYSSGLAAIY GLLSYLNPKH IAVHKPGFGG
     YSGTIQIIAR INRLTGLETS FIDGKCDAIG EGDVIWLETP LNPLGIAFDI PFYKELAKKK
     GAILVVDSTF APPPIQDALV LGADYVVHSA TKYLAGHSDV LAGVTASKDR SKILDLKADR
     AYLGTILHPQ QAFLLLRSLR TFPLRIAKHS ENGFLVAQHL NKLATDEQFA TSLGIDSSLI
     LEVYHNSLQT KEFVAKNLTG GHASCFSVLL KSDTVAKHLC CELKYFHHAT SLGSVESLIE
     WRRMTDSKID PRLVRLSIGI EDAADLIADL NRVFASLS