ID   YFHH_ECOLI              Reviewed;         282 AA.
AC   P37767; P76588; Q2MAG9;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YfhH;
GN   Name=yfhH; OrderedLocusNames=b2561, JW2545;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Nashimoto H., Saito N.;
RL   Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91.
RC   STRAIN=NWL37;
RX   PubMed=1602968; DOI=10.1111/j.1365-2958.1992.tb01540.x;
RA   Poulsen L.K., Larsen N.W., Molin S., Andersson P.;
RT   "Analysis of an Escherichia coli mutant strain resistant to the cell-
RT   killing function encoded by the gef gene family.";
RL   Mol. Microbiol. 6:895-905(1992).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA79823.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA10911.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; D64044; BAA10911.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U36841; AAA79823.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC75614.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76737.1; -; Genomic_DNA.
DR   EMBL; X72336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_417056.2; NC_000913.3.
DR   RefSeq; WP_001013779.1; NZ_STEB01000011.1.
DR   AlphaFoldDB; P37767; -.
DR   SMR; P37767; -.
DR   BioGRID; 4261197; 14.
DR   DIP; DIP-12050N; -.
DR   STRING; 511145.b2561; -.
DR   jPOST; P37767; -.
DR   PaxDb; P37767; -.
DR   PRIDE; P37767; -.
DR   EnsemblBacteria; AAC75614; AAC75614; b2561.
DR   EnsemblBacteria; BAE76737; BAE76737; BAE76737.
DR   GeneID; 66673551; -.
DR   GeneID; 947030; -.
DR   KEGG; ecj:JW2545; -.
DR   KEGG; eco:b2561; -.
DR   PATRIC; fig|1411691.4.peg.4173; -.
DR   EchoBASE; EB2214; -.
DR   eggNOG; COG1737; Bacteria.
DR   HOGENOM; CLU_055769_0_2_6; -.
DR   InParanoid; P37767; -.
DR   OMA; QDLEHAP; -.
DR   PhylomeDB; P37767; -.
DR   BioCyc; EcoCyc:EG12308-MON; -.
DR   PRO; PR:P37767; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd05013; SIS_RpiR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR000281; HTH_RpiR.
DR   InterPro; IPR035472; RpiR-like_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01418; HTH_6; 1.
DR   Pfam; PF01380; SIS; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51071; HTH_RPIR; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YfhH"
FT                   /id="PRO_0000068626"
FT   DOMAIN          1..77
FT                   /note="HTH rpiR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT   DOMAIN          125..265
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DNA_BIND        37..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
SQ   SEQUENCE   282 AA;  30708 MW;  FF0AE2A0BF4E3C48 CRC64;
     MNGLLRIRQR YQGLAQSDKK LADYLLLQPD TARHLSSQQL ANEAGVSQSS VVKFAQKLGY
     KGFPALKLAL SEALASQPES PSVPIHNQIR GDDPLRLVGE KLIKENTAAM YATLNVNSEE
     KLHECVTMLR SARRIILTGI GASGLVAQNF AWKLMKIGFN AAAVRDMHAL LATVQASSPD
     DLLLAISYTG VRRELNLAAD EMLRVGGKVL AITGFTPNAL QQRASHCLYT IAEEQATNSA
     SISACHAQGM LTDLLFIALI QQDLELAPER IRHSEALVKK LV