YFHH_SCHPO
ID YFHH_SCHPO Reviewed; 1611 AA.
AC O42854;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=SH3 domain-containing protein C23A1.17;
GN ORFNames=SPAC23A1.17;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258; SER-1261; SER-1266;
RP SER-1379 AND THR-1380, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Note=Localizes at the cell tip and barrier septum.
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DR EMBL; CU329670; CAA16991.1; -; Genomic_DNA.
DR PIR; T38236; T38236.
DR RefSeq; NP_594446.1; NM_001019875.2.
DR AlphaFoldDB; O42854; -.
DR SMR; O42854; -.
DR BioGRID; 278502; 11.
DR STRING; 4896.SPAC23A1.17.1; -.
DR iPTMnet; O42854; -.
DR MaxQB; O42854; -.
DR PaxDb; O42854; -.
DR PRIDE; O42854; -.
DR EnsemblFungi; SPAC23A1.17.1; SPAC23A1.17.1:pep; SPAC23A1.17.
DR GeneID; 2542019; -.
DR KEGG; spo:SPAC23A1.17; -.
DR PomBase; SPAC23A1.17; -.
DR VEuPathDB; FungiDB:SPAC23A1.17; -.
DR eggNOG; ENOG502QQMM; Eukaryota.
DR HOGENOM; CLU_243881_0_0_1; -.
DR InParanoid; O42854; -.
DR OMA; FSDWAHG; -.
DR Reactome; R-SPO-5668599; RHO GTPases Activate NADPH Oxidases.
DR PRO; PR:O42854; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0017024; F:myosin I binding; ISO:PomBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:PomBase.
DR CDD; cd11887; SH3_Bbc1; 1.
DR InterPro; IPR035552; Mti1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome; SH3 domain.
FT CHAIN 1..1611
FT /note="SH3 domain-containing protein C23A1.17"
FT /id="PRO_0000303941"
FT DOMAIN 3..67
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 275..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..417
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..977
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1245
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1258
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1261
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1266
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1379
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1380
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 1611 AA; 170527 MW; B3DEF9F83C1A7542 CRC64;
MSSFPTRVVA LYPYRSSFSD DLEFDPGQVI DVVSNLDGDW YTGTYVDSDG NRKIGSFPKD
FTEPAEDAVF VERASEMALH QPTPTSAVHS RNSSLGYAPS ITRSIKSISN NTEHLGADTE
SYLSANDFID STSEALTKIV DVDTLSAPFG NDSNSRPHSL KNVEKLHTFS APYTISEETP
SCSTENDSLP LTATHTITGG EDAATGAAVT NTTTTHITTS TNTSTVIPSN PNSVFLVDCT
HSQCPTDLPN IATTQHSLRY LDNASASAIT VLERTHPAAS STMATESSHQ SPSADSQAEE
LSKSQRVAKD DDPFVVSNTA NSDEPASSSK PAKPLTDLNR AFSQRLNLDP QKPGKSQGEI
SEQEEDEYDD AESDEMHSPY STHEPESEPE DQDEPSEKDD ENKDVEEEQE QEQEEEQIDP
EEAKRIALRE RMAKMSGGIG MHVFGLPGLA APIGRKNTLR RTPAKSSEEA KSTTNDSSPP
KDSSSTSTQP TEQSNAQQAP SPKEEERPLP SEPSQNQPAE YRDTPDTPRN IMPLPGLMSA
DQPIKVTEPS NDADKAIVAE GPNNEEETKG PVIPETQETS EQQVHKTPSP EKQKVLSPPP
IITNFDKETL ASNEAHEAVP QKPSAPQVTR LMAPQDSSSV VTPSPTSLLD PARAVRKVID
GIDPPKEAGA GATADVESAA NSPITPPRTW HSPDFTSKSF EPIERKLPSR ISEVTEDSID
EDKQNEVDPS TSARALPPPG LRFGKVDTLA SLAHDDLDDL PAVPRIFSPP PLPKTPSGEF
GDNEFMFPKK SNRVRGHQSR PSTGSQLRNV VPVSIVTSGG RPALPDEMAS PSSSIGHPLP
SPPPADFNSL NVDFYEPHSY LESPAPEPQP SYEEESFNAT VIHAPTPSTA TFQGHPTISN
VATPPLKQDV TESKASPVAD ASATHQSSTG LTQEITQLGS NMRLPTKLTR PSNDGRKASG
PRPAAPPSIP PPLPVSNILS SPTSEPPKDH PPSAPLSKPV STSPAAPLAR VPPVPKLSSK
APPVPLPSAD APPIPVPSTA PPVPIPTSTP PVPKSSSGAP SAPPPVPAPS SEIPSIPAPS
GAPPVPAPSG IPPVPKPSVA APPVPKPSVA VPPVPAPSGA PPVPKPSVAA PPVPVPSGAP
PVPKPSVAAP PVPAPSGAPP VPKPSVAAPP VPAPSSGIPP VPKPAAGVPP VPPPSEAPPV
PKPSVGVPPV PPPSTAPPVP TPSAGLPPVP VPTAKAPPVP APSSEAPSVS TPRSSVPSPH
SNASPSPTSS SMASAAPART SVSRSKSKAE RHETSTSSRK SSKSGEHHHH HNEGHADSSS
TRTSLAHQDS RKSLHRHLSR SSSRASKKPS IVSTTGPFNE SFSAKPVEPC ASEKWWLNST
AVPKSVVQMN DSVLYMIKEG ITGQDKKYKS VHILFPDYSQ TVLTATFNPH NQNITQLSQL
QLAPPAQPSK ARLDEEYACY GSTILKKARA YQGSMVGDGS AFTFVNSVMS ILAHNLEPIN
KQTFGGVIYK NVGNVTVQQI GEIRPGDIVT FDKAKFSGQK GTLRSKYSLE VGKPMHYGII
SEWDVSKLKI RVLEQGRESK KVSVASYKFG DLKSGEVTVW RVMRRSWLGW N
