ID   YFHM_BACSU              Reviewed;         286 AA.
AC   O31581; Q79EV6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=AB hydrolase superfamily protein YfhM;
DE            EC=3.-.-.-;
GN   Name=yfhM; OrderedLocusNames=BSU08590;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8946165; DOI=10.1093/dnares/3.4.257;
RA   Yamamoto H., Uchiyama S., Sekiguchi J.;
RT   "Cloning and sequencing of a 27.8-kb nucleotide sequence of the 79 degrees-
RT   81 degrees region of the Bacillus subtilis genome containing the sspE
RT   locus.";
RL   DNA Res. 3:257-262(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Epoxide hydrolase
CC       family. {ECO:0000305}.
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DR   EMBL; D85082; BAA24479.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12687.1; -; Genomic_DNA.
DR   PIR; F69801; F69801.
DR   RefSeq; NP_388739.1; NC_000964.3.
DR   RefSeq; WP_003243419.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; O31581; -.
DR   SMR; O31581; -.
DR   STRING; 224308.BSU08590; -.
DR   ESTHER; bacsu-yfhM; Epoxide_hydrolase.
DR   PaxDb; O31581; -.
DR   PRIDE; O31581; -.
DR   EnsemblBacteria; CAB12687; CAB12687; BSU_08590.
DR   GeneID; 936187; -.
DR   KEGG; bsu:BSU08590; -.
DR   PATRIC; fig|224308.179.peg.927; -.
DR   eggNOG; COG0596; Bacteria.
DR   InParanoid; O31581; -.
DR   OMA; YRWMVRS; -.
DR   PhylomeDB; O31581; -.
DR   BioCyc; BSUB:BSU08590-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..286
FT                   /note="AB hydrolase superfamily protein YfhM"
FT                   /id="PRO_0000360534"
FT   DOMAIN          27..272
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        103
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        210
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        265
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   286 AA;  32758 MW;  EE6F5A49406CF639 CRC64;
     MDGVKCQFVN TNGITLHVAA AGREDGPLIV LLHGFPEFWY GWKNQIKPLV DAGYRVIAPD
     QRGYNLSDKP EGIDSYRIDT LRDDIIGLIT QFTDEKAIVI GHDWGGAVAW HLASTRPEYL
     EKLIAINIPH PHVMKTVTPL YPPQWLKSSY IAYFQLPDIP EASLRENDYD TLDKAIGLSD
     RPALFTSEDV SRYKEAWKQP GALTAMLNWY RALRKGSLAE KPSYETVPYR MIWGMEDRFL
     SRKLAKETER HCPNGHLIFV DEASHWINHE KPAIVNQLIL EYLKNQ