YFHP_BACSU
ID YFHP_BACSU Reviewed; 327 AA.
AC O31583; Q79EV4;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Uncharacterized protein YfhP;
GN Name=yfhP; OrderedLocusNames=BSU08620;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / AC327;
RX PubMed=8946165; DOI=10.1093/dnares/3.4.257;
RA Yamamoto H., Uchiyama S., Sekiguchi J.;
RT "Cloning and sequencing of a 27.8-kb nucleotide sequence of the 79 degrees-
RT 81 degrees region of the Bacillus subtilis genome containing the sspE
RT locus.";
RL DNA Res. 3:257-262(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INDUCTION BY SIGMA-K.
RC STRAIN=168 / JH642;
RX PubMed=10524235; DOI=10.1016/s0378-1119(99)00300-5;
RA Fujita M.;
RT "Identification of new sigmaK-dependent promoters using an in vitro
RT transcription system derived from Bacillus subtilis.";
RL Gene 237:45-52(1999).
RN [4]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=10463184; DOI=10.1099/13500872-145-8-2171;
RA Yamamoto H., Mori M., Sekiguchi J.;
RT "Transcription of genes near the sspE locus of the Bacillus subtilis
RT genome.";
RL Microbiology 145:2171-2180(1999).
CC -!- FUNCTION: May act as a negative regulator for the transcription of
CC mutY, fabL, sspE and yfhP. {ECO:0000269|PubMed:10463184}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Autoregulated. Transcriptionally regulated by sigma-K.
CC Expressed during exponential growth. {ECO:0000269|PubMed:10463184,
CC ECO:0000269|PubMed:10524235}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene display increased rates
CC of transcription of mutY, fabL, sspE and yfhP.
CC {ECO:0000269|PubMed:10463184}.
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DR EMBL; D85082; BAA24482.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12690.1; -; Genomic_DNA.
DR PIR; H69801; H69801.
DR RefSeq; NP_388742.1; NC_000964.3.
DR RefSeq; WP_003244136.1; NZ_JNCM01000032.1.
DR AlphaFoldDB; O31583; -.
DR STRING; 224308.BSU08620; -.
DR PaxDb; O31583; -.
DR PRIDE; O31583; -.
DR EnsemblBacteria; CAB12690; CAB12690; BSU_08620.
DR GeneID; 936190; -.
DR KEGG; bsu:BSU08620; -.
DR PATRIC; fig|224308.179.peg.930; -.
DR eggNOG; COG1988; Bacteria.
DR InParanoid; O31583; -.
DR OMA; TGWVFSE; -.
DR PhylomeDB; O31583; -.
DR BioCyc; BSUB:BSU08620-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007404; YdjM-like.
DR Pfam; PF04307; YdjM; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..327
FT /note="Uncharacterized protein YfhP"
FT /id="PRO_0000387956"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 37128 MW; 4A2C5D8FE36019B4 CRC64;
MDTGTHVVMG IALGGIATLD PVVGSDPAMA HAVMIATLAG SQAPDIDTVL KLKNNAVYIR
NHRGFTHSIP AVLFWSVIIP AILYLFYPQA DFLHLWLWTL LAVVLHVFVD IFNAYGTQAI
RPFSKKWVAL GLINTFDPFI FISHLAAIAI WYAGGSPGIT FLSLYIILVG YYLVRLIMQL
RIKRKLHEMI HDEIESIIIS PTMKFRQWRI AVTTAHAFYV GRSMEGHVVI LDTFNRVPVP
ETDVMHAAKQ DDNIAAFLSF SPVYRWEVDT FKDHYEVRFI DLRYRSKGHY PFVAIVHIGH
DLTIRSSYTG WIFSEEKLQK KLKLGSI
