ID   YFI3_SCHPO              Reviewed;         270 AA.
AC   O94437;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Abhydrolase domain-containing protein C22H12.03;
DE            EC=3.1.-.-;
GN   ORFNames=SPAC22H12.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA22555.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000255}.
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DR   EMBL; CU329670; CAA22555.1; -; Genomic_DNA.
DR   PIR; T38218; T38218.
DR   RefSeq; NP_593115.1; NM_001018512.2.
DR   AlphaFoldDB; O94437; -.
DR   SMR; O94437; -.
DR   STRING; 4896.SPAC22H12.03.1; -.
DR   ESTHER; schpo-C22H12.03; ABHD11-Acetyl_transferase.
DR   MaxQB; O94437; -.
DR   PaxDb; O94437; -.
DR   EnsemblFungi; SPAC22H12.03.1; SPAC22H12.03.1:pep; SPAC22H12.03.
DR   PomBase; SPAC22H12.03; -.
DR   VEuPathDB; FungiDB:SPAC22H12.03; -.
DR   eggNOG; KOG2382; Eukaryota.
DR   HOGENOM; CLU_020336_53_0_1; -.
DR   InParanoid; O94437; -.
DR   OMA; MMYFARK; -.
DR   PhylomeDB; O94437; -.
DR   Reactome; R-SPO-426048; Arachidonate production from DAG.
DR   PRO; PR:O94437; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; ISS:PomBase.
DR   GO; GO:0046464; P:acylglycerol catabolic process; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; ISS:PomBase.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Mitochondrion; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Abhydrolase domain-containing protein C22H12.03"
FT                   /id="PRO_0000312657"
FT   DOMAIN          21..257
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        95
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q6DRD9"
FT   ACT_SITE        190
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q6DRD9"
FT   ACT_SITE        250
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:Q6DRD9"
SQ   SEQUENCE   270 AA;  30750 MW;  D3AF086BC334B272 CRC64;
     MSLKPVKLAF EKYSATVAKH PPVLIFHGLL GSKRNWRSLA KKFSCKLDRD IYAIDQRCHG
     DSPCVAPLSY SAMALDAFQF MKDHKLDKAS IIGHSMGAKT AMVTALKWPD KVEKLVVVDN
     SPWYQDLPRD YGAYFRKMIQ IDEANITKYS EADKMMSTVE KDILVRSFLL SNLKKDSNNS
     NTFKFRVPIE LISKSLKTIE GFPASLNDLV YDSPTLVIRA LKAPFIPDSA LPVFKKFFPK
     YELVSLDCGH WVHFEKPKEF SESIINFLNN