ID   YFIA_ECO57              Reviewed;         113 AA.
AC   P0AD51; P11285;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Ribosome-associated factor Y {ECO:0000305};
DE            Short=pY;
DE   AltName: Full=Ribosome associated inhibitor A;
GN   Name=yfiA {ECO:0000305}; Synonyms=raiA; OrderedLocusNames=Z3890, ECs3460;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: During stationary phase, prevents 70S dimer formation,
CC       probably in order to regulate translation efficiency during transition
CC       between the exponential and the stationary phases. In addition, during
CC       environmental stress such as cold shock or excessive cell density at
CC       stationary phase, stabilizes the 70S ribosome against dissociation,
CC       inhibits translation initiation and increase translation accuracy. When
CC       normal growth conditions are restored, is quickly released from the
CC       ribosome (By similarity). {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- SUBUNIT: Associates mainly with 70S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- INDUCTION: By environmental stress and during stationary phase.
CC       {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       YfiA subfamily. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57709.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36883.1; -; Genomic_DNA.
DR   PIR; A85906; A85906.
DR   PIR; D91061; D91061.
DR   RefSeq; NP_311487.1; NC_002695.1.
DR   RefSeq; WP_000178456.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AD51; -.
DR   BMRB; P0AD51; -.
DR   SMR; P0AD51; -.
DR   STRING; 155864.EDL933_3759; -.
DR   EnsemblBacteria; AAG57709; AAG57709; Z3890.
DR   EnsemblBacteria; BAB36883; BAB36883; ECs_3460.
DR   GeneID; 67414085; -.
DR   GeneID; 914860; -.
DR   KEGG; ece:Z3890; -.
DR   KEGG; ecs:ECs_3460; -.
DR   PATRIC; fig|386585.9.peg.3615; -.
DR   eggNOG; COG1544; Bacteria.
DR   HOGENOM; CLU_071472_3_0_6; -.
DR   OMA; DMYVAIN; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Acetylation; Reference proteome; Stress response; Translation regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..113
FT                   /note="Ribosome-associated factor Y"
FT                   /id="PRO_0000169262"
FT   REGION          91..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         66
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12785 MW;  562901F819836A87 CRC64;
     MTMNITSKQM EITPAIRQHV ADRLAKLEKW QTHLINPHII LSKEPQGFVA DATINTPNGV
     LVASGKHEDM YTAINELINK LERQLNKLQH KGEARRAATS VKDANFVEEV EEE