ID   YFIA_ECOL6              Reviewed;         113 AA.
AC   P0AD50; P11285;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Ribosome-associated factor Y {ECO:0000305};
DE            Short=pY;
DE   AltName: Full=Ribosome associated inhibitor A;
GN   Name=yfiA {ECO:0000305}; Synonyms=raiA; OrderedLocusNames=c3119;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: During stationary phase, prevents 70S dimer formation,
CC       probably in order to regulate translation efficiency during transition
CC       between the exponential and the stationary phases. In addition, during
CC       environmental stress such as cold shock or excessive cell density at
CC       stationary phase, stabilizes the 70S ribosome against dissociation,
CC       inhibits translation initiation and increase translation accuracy. When
CC       normal growth conditions are restored, is quickly released from the
CC       ribosome (By similarity). {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- SUBUNIT: Associates mainly with 70S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- INDUCTION: By environmental stress and during stationary phase.
CC       {ECO:0000250|UniProtKB:P0AD49}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       YfiA subfamily. {ECO:0000305}.
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DR   EMBL; AE014075; AAN81568.1; -; Genomic_DNA.
DR   RefSeq; WP_000178456.1; NC_004431.1.
DR   AlphaFoldDB; P0AD50; -.
DR   BMRB; P0AD50; -.
DR   SMR; P0AD50; -.
DR   STRING; 199310.c3119; -.
DR   EnsemblBacteria; AAN81568; AAN81568; c3119.
DR   GeneID; 67414085; -.
DR   KEGG; ecc:c3119; -.
DR   eggNOG; COG1544; Bacteria.
DR   HOGENOM; CLU_071472_3_0_6; -.
DR   OMA; DMYVAIN; -.
DR   BioCyc; ECOL199310:C3119-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Acetylation; Stress response; Translation regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..113
FT                   /note="Ribosome-associated factor Y"
FT                   /id="PRO_0000169263"
FT   REGION          91..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         66
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12785 MW;  562901F819836A87 CRC64;
     MTMNITSKQM EITPAIRQHV ADRLAKLEKW QTHLINPHII LSKEPQGFVA DATINTPNGV
     LVASGKHEDM YTAINELINK LERQLNKLQH KGEARRAATS VKDANFVEEV EEE