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YFIR_BACSU
ID   YFIR_BACSU              Reviewed;         205 AA.
AC   O31560; Q79EW9;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YfiR;
GN   Name=yfiR; OrderedLocusNames=BSU08370;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8946165; DOI=10.1093/dnares/3.4.257;
RA   Yamamoto H., Uchiyama S., Sekiguchi J.;
RT   "Cloning and sequencing of a 27.8-kb nucleotide sequence of the 79 degrees-
RT   81 degrees region of the Bacillus subtilis genome containing the sspE
RT   locus.";
RL   DNA Res. 3:257-262(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=15944459; DOI=10.1128/mmbr.69.2.326-356.2005;
RA   Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K.,
RA   Zhang X., Gallegos M.T., Brennan R., Tobes R.;
RT   "The TetR family of transcriptional repressors.";
RL   Microbiol. Mol. Biol. Rev. 69:326-356(2005).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
RX   PubMed=16862575; DOI=10.1002/prot.21073;
RA   Rajan S.S., Yang X., Shuvalova L., Collart F., Anderson W.F.;
RT   "Crystal structure of YfiR, an unusual TetR/CamR-type putative
RT   transcriptional regulator from Bacillus subtilis.";
RL   Proteins 65:255-257(2006).
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DR   EMBL; D85082; BAA24458.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12666.1; -; Genomic_DNA.
DR   PIR; D69804; D69804.
DR   RefSeq; NP_388718.1; NC_000964.3.
DR   RefSeq; WP_003243967.1; NZ_JNCM01000032.1.
DR   PDB; 1RKT; X-ray; 1.95 A; A/B=1-205.
DR   PDBsum; 1RKT; -.
DR   AlphaFoldDB; O31560; -.
DR   SMR; O31560; -.
DR   STRING; 224308.BSU08370; -.
DR   PaxDb; O31560; -.
DR   PRIDE; O31560; -.
DR   EnsemblBacteria; CAB12666; CAB12666; BSU_08370.
DR   GeneID; 936176; -.
DR   KEGG; bsu:BSU08370; -.
DR   PATRIC; fig|224308.179.peg.905; -.
DR   eggNOG; COG1309; Bacteria.
DR   InParanoid; O31560; -.
DR   OMA; YEYSFTH; -.
DR   PhylomeDB; O31560; -.
DR   BioCyc; BSUB:BSU08370-MON; -.
DR   EvolutionaryTrace; O31560; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR041612; YfiR_C.
DR   Pfam; PF17922; TetR_C_17; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YfiR"
FT                   /id="PRO_0000360710"
FT   DOMAIN          11..71
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   HELIX           6..28
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           35..42
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           46..50
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           56..78
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   TURN            79..81
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           84..98
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   TURN            99..101
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           102..104
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           107..115
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           116..119
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           121..147
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           157..177
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           180..183
FT                   /evidence="ECO:0007829|PDB:1RKT"
FT   HELIX           185..200
FT                   /evidence="ECO:0007829|PDB:1RKT"
SQ   SEQUENCE   205 AA;  23684 MW;  3D075561981F49D0 CRC64;
     MSPKVTKEHK DKRQAEILEA AKTVFKRKGF ELTTMKDVVE ESGFSRGGVY LYFSSTEEMF
     RRIIETGLDE GLRKLDKSAE HQSVWASISS YLDELTEGLR DVADTLAPVQ FEYLVTAWRN
     EERRQYLEKR YDLFVERFSR LLQKGIDQGE FQPVQPLATI AKFFLNMNDG IIQNALYFDE
     EKADVSGLAE SAKLYLKTVL QADEK
 
 
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