YFIR_BACSU
ID YFIR_BACSU Reviewed; 205 AA.
AC O31560; Q79EW9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized HTH-type transcriptional regulator YfiR;
GN Name=yfiR; OrderedLocusNames=BSU08370;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8946165; DOI=10.1093/dnares/3.4.257;
RA Yamamoto H., Uchiyama S., Sekiguchi J.;
RT "Cloning and sequencing of a 27.8-kb nucleotide sequence of the 79 degrees-
RT 81 degrees region of the Bacillus subtilis genome containing the sspE
RT locus.";
RL DNA Res. 3:257-262(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP REVIEW, AND GENE FAMILY.
RX PubMed=15944459; DOI=10.1128/mmbr.69.2.326-356.2005;
RA Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K.,
RA Zhang X., Gallegos M.T., Brennan R., Tobes R.;
RT "The TetR family of transcriptional repressors.";
RL Microbiol. Mol. Biol. Rev. 69:326-356(2005).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
RX PubMed=16862575; DOI=10.1002/prot.21073;
RA Rajan S.S., Yang X., Shuvalova L., Collart F., Anderson W.F.;
RT "Crystal structure of YfiR, an unusual TetR/CamR-type putative
RT transcriptional regulator from Bacillus subtilis.";
RL Proteins 65:255-257(2006).
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DR EMBL; D85082; BAA24458.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12666.1; -; Genomic_DNA.
DR PIR; D69804; D69804.
DR RefSeq; NP_388718.1; NC_000964.3.
DR RefSeq; WP_003243967.1; NZ_JNCM01000032.1.
DR PDB; 1RKT; X-ray; 1.95 A; A/B=1-205.
DR PDBsum; 1RKT; -.
DR AlphaFoldDB; O31560; -.
DR SMR; O31560; -.
DR STRING; 224308.BSU08370; -.
DR PaxDb; O31560; -.
DR PRIDE; O31560; -.
DR EnsemblBacteria; CAB12666; CAB12666; BSU_08370.
DR GeneID; 936176; -.
DR KEGG; bsu:BSU08370; -.
DR PATRIC; fig|224308.179.peg.905; -.
DR eggNOG; COG1309; Bacteria.
DR InParanoid; O31560; -.
DR OMA; YEYSFTH; -.
DR PhylomeDB; O31560; -.
DR BioCyc; BSUB:BSU08370-MON; -.
DR EvolutionaryTrace; O31560; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR041612; YfiR_C.
DR Pfam; PF17922; TetR_C_17; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..205
FT /note="Uncharacterized HTH-type transcriptional regulator
FT YfiR"
FT /id="PRO_0000360710"
FT DOMAIN 11..71
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT HELIX 6..28
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 35..42
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 46..50
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 56..78
FT /evidence="ECO:0007829|PDB:1RKT"
FT TURN 79..81
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 84..98
FT /evidence="ECO:0007829|PDB:1RKT"
FT TURN 99..101
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 107..115
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 116..119
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 121..147
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 157..177
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 180..183
FT /evidence="ECO:0007829|PDB:1RKT"
FT HELIX 185..200
FT /evidence="ECO:0007829|PDB:1RKT"
SQ SEQUENCE 205 AA; 23684 MW; 3D075561981F49D0 CRC64;
MSPKVTKEHK DKRQAEILEA AKTVFKRKGF ELTTMKDVVE ESGFSRGGVY LYFSSTEEMF
RRIIETGLDE GLRKLDKSAE HQSVWASISS YLDELTEGLR DVADTLAPVQ FEYLVTAWRN
EERRQYLEKR YDLFVERFSR LLQKGIDQGE FQPVQPLATI AKFFLNMNDG IIQNALYFDE
EKADVSGLAE SAKLYLKTVL QADEK