ID   CBF2_CAMJE              Reviewed;         273 AA.
AC   Q0PAS1; Q46105;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Putative peptidyl-prolyl cis-trans isomerase Cbf2;
DE            Short=PPIase Cbf2;
DE            EC=5.2.1.8;
DE   AltName: Full=Cell-binding factor 2;
DE   AltName: Full=Major antigen peb4A;
DE   AltName: Full=Rotamase Cbf2;
DE   Flags: Precursor;
GN   Name=cbf2; Synonyms=peb4A; OrderedLocusNames=Cj0596;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
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DR   EMBL; AL111168; CAL34742.1; -; Genomic_DNA.
DR   PIR; S52412; S52412.
DR   RefSeq; WP_002852119.1; NC_002163.1.
DR   RefSeq; YP_002344026.1; NC_002163.1.
DR   PDB; 3RFW; X-ray; 2.20 A; A=22-273.
DR   PDBsum; 3RFW; -.
DR   AlphaFoldDB; Q0PAS1; -.
DR   SMR; Q0PAS1; -.
DR   IntAct; Q0PAS1; 60.
DR   STRING; 192222.Cj0596; -.
DR   PaxDb; Q0PAS1; -.
DR   PRIDE; Q0PAS1; -.
DR   DNASU; 904921; -.
DR   EnsemblBacteria; CAL34742; CAL34742; Cj0596.
DR   GeneID; 904921; -.
DR   KEGG; cje:Cj0596; -.
DR   PATRIC; fig|192222.6.peg.588; -.
DR   eggNOG; COG0760; Bacteria.
DR   HOGENOM; CLU_034646_1_2_7; -.
DR   OMA; YEQAKPT; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   InterPro; IPR023058; PPIase_PpiC_CS.
DR   PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Isomerase; Reference proteome; Rotamase; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..273
FT                   /note="Putative peptidyl-prolyl cis-trans isomerase Cbf2"
FT                   /id="PRO_0000025546"
FT   DOMAIN          131..228
FT                   /note="PpiC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
FT   STRAND          23..27
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          30..33
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           34..45
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           50..52
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           55..77
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           80..82
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           84..107
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           114..124
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           125..127
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          128..130
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          133..143
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           144..154
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           159..173
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   TURN            177..179
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           180..182
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          185..189
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          191..194
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           196..204
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          215..217
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   STRAND          220..230
FT                   /evidence="ECO:0007829|PDB:3RFW"
FT   HELIX           237..267
FT                   /evidence="ECO:0007829|PDB:3RFW"
SQ   SEQUENCE   273 AA;  30518 MW;  1C014658BBCD4E39 CRC64;
     MKKFSLVAAT LIAGVVLNVN AATVATVNGK SISDTEVSEF FAPMLRGQDF KTLPDNQKKA
     LIQQYIMQDL ILQDAKKQNL EKDPLYTKEL DRAKDAILVN VYQEKILNTI KIDAAKVKAF
     YDQNKDKYVK PARVQAKHIL VATEKEAKDI INELKGLKGK ELDAKFSELA KEKSIDPGSK
     NQGGELGWFD QSTMVKPFTD AAFALKNGTI TTTPVKTNFG YHVILKENSQ AKGQIKFDEV
     KQGIENGLKF EEFKKVINQK GQDLLNSAKV EYK