YFL5_YEAST
ID YFL5_YEAST Reviewed; 309 AA.
AC P43617; D6VTS8; Q96US0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Uncharacterized mitochondrial carrier YFR045W;
GN OrderedLocusNames=YFR045W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686379;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<149::aid-yea893>3.0.co;2-g;
RA Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.;
RT "Analysis of a 36.2 kb DNA sequence including the right telomere of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:149-167(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-309, AND IDENTIFICATION OF
RP FRAMESHIFT.
RX PubMed=10930523; DOI=10.1016/s0005-2736(00)00222-4;
RA Belenkiy R., Haefele A., Eisen M.B., Wohlrab H.;
RT "The yeast mitochondrial transport proteins: new sequences and consensus
RT residues, lack of direct relation between consensus residues and
RT transmembrane helices, expression patterns of the transport protein genes,
RT and protein-protein interactions with other proteins.";
RL Biochim. Biophys. Acta 1467:207-218(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-309.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP IDENTIFICATION OF INTRON.
RX PubMed=17101987; DOI=10.1073/pnas.0605645103;
RA Miura F., Kawaguchi N., Sese J., Toyoda A., Hattori M., Morishita S.,
RA Ito T.;
RT "A large-scale full-length cDNA analysis to explore the budding yeast
RT transcriptome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:17846-17851(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL26494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA09284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAA09284.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D50617; BAA09284.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF419345; AAL26494.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY558474; AAS56800.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12488.1; -; Genomic_DNA.
DR PIR; S56300; S56300.
DR RefSeq; NP_116703.5; NM_001180010.3.
DR AlphaFoldDB; P43617; -.
DR SMR; P43617; -.
DR BioGRID; 31203; 99.
DR DIP; DIP-5570N; -.
DR STRING; 4932.YFR045W; -.
DR MaxQB; P43617; -.
DR PaxDb; P43617; -.
DR PRIDE; P43617; -.
DR EnsemblFungi; YFR045W_mRNA; YFR045W; YFR045W.
DR GeneID; 850606; -.
DR KEGG; sce:YFR045W; -.
DR SGD; S000001941; YFR045W.
DR VEuPathDB; FungiDB:YFR045W; -.
DR eggNOG; KOG0756; Eukaryota.
DR HOGENOM; CLU_015166_5_1_1; -.
DR InParanoid; P43617; -.
DR OMA; TRMQSKY; -.
DR BioCyc; YEAST:G3O-30492-MON; -.
DR PRO; PR:P43617; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43617; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:SGD.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0071913; F:citrate secondary active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006843; P:mitochondrial citrate transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; ISS:SGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Uncharacterized mitochondrial carrier YFR045W"
FT /id="PRO_0000090695"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 6..83
FT /note="Solcar 1"
FT REPEAT 97..211
FT /note="Solcar 2"
FT REPEAT 216..302
FT /note="Solcar 3"
SQ SEQUENCE 309 AA; 34391 MW; 3E91A548BD4634EC CRC64;
MANQNSDLYK QITAGSVAAV FQTTMTYPFE YLKTGLQLQP KGTAFEIILP QIKSYFVGCS
ALNVAAFGKT ILRFVTFDKL CHSLNNNIDN NDNFQRLTGY NLLIAGTLTG IVESLFIIPF
ENIKTTLIQS AMIDHKKLEK NQPVVNAKAT FHKVATKSTP VARIEKLLPA VKHMYQTRGP
AAFVQGTTAT IFRQIANTSI QFTAYTAFKR LLQARNDKAS SVITGLATSF TLVAMTQPID
VVKTRMMSQN AKTEYKNTLN CMYRIFVQEG MATFWKGSIF RFMKVGISGG LTFTVYEQVS
LLLGFSSRS
