YFMO_BACSU
ID YFMO_BACSU Reviewed; 396 AA.
AC O06473;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Multidrug efflux protein YfmO;
GN Name=yfmO; OrderedLocusNames=BSU07400;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / AC327;
RX PubMed=9141694; DOI=10.1099/00221287-143-4-1317;
RA Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.;
RT "A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus
RT subtilis genome.";
RL Microbiology 143:1317-1320(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RC STRAIN=168;
RX PubMed=14663075; DOI=10.1099/mic.0.26225-0;
RA Gaballa A., Cao M., Helmann J.D.;
RT "Two MerR homologues that affect copper induction of the Bacillus subtilis
RT copZA operon.";
RL Microbiology 149:3413-3421(2003).
CC -!- FUNCTION: Acts to efflux copper or a copper complex. It is possible
CC that YfmO could contribute to copper resistance.
CC {ECO:0000269|PubMed:14663075}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- INDUCTION: Repressed by YfmP.
CC -!- MISCELLANEOUS: Cotranscribed with yfmP.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; D86418; BAA20104.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12559.1; -; Genomic_DNA.
DR PIR; F69813; F69813.
DR RefSeq; NP_388621.1; NC_000964.3.
DR RefSeq; WP_003233759.1; NZ_JNCM01000032.1.
DR AlphaFoldDB; O06473; -.
DR SMR; O06473; -.
DR STRING; 224308.BSU07400; -.
DR TCDB; 2.A.1.32.3; the major facilitator superfamily (mfs).
DR PaxDb; O06473; -.
DR PRIDE; O06473; -.
DR EnsemblBacteria; CAB12559; CAB12559; BSU_07400.
DR GeneID; 936111; -.
DR KEGG; bsu:BSU07400; -.
DR PATRIC; fig|224308.179.peg.802; -.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; O06473; -.
DR OMA; WAVAFAC; -.
DR PhylomeDB; O06473; -.
DR BioCyc; BSUB:BSU07400-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 2.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Copper; Copper transport; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..396
FT /note="Multidrug efflux protein YfmO"
FT /id="PRO_0000084883"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 396 AA; 41451 MW; CA88EBA40A0F4E69 CRC64;
MDKTTQVNQK TGLLSQPKAV WAVAFACVIS FMGIGLVDPI LPAIAAQLHA SPSEVSLLFT
SYLLVTGFMM FFSGAISSRI GAKWTLILGL IFIIVFAGLG GSSSSIAQLV GYRGGWGLGN
ALFISTALAV IVGVSVGGSA QAIILYEAAL GLGISVGPLA GGELGSISWR APFFGVSVLM
FIALIAISFM LPKLPKPAKR VGVFDAMKAL KYKGLLTMAV SAFLYNFGFF ILLAYSPFVL
DLDEHGLGYV FFGWGLLLAI TSVFTAPLVH KALGTVRSLV VLFIAFAAIL VIMGIWTDHQ
TLIITCIVVA GAVLGMVNTI MTTAVMGSAP VERSIASSAY SSVRFIGGAL APWIAGMLSE
HFTASTPYTV GGIVVFVGML VLLMGRKHLA GIKAGH
