ID   YFMP_BACSU              Reviewed;         140 AA.
AC   O06474;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=HTH-type transcriptional regulator YfmP;
GN   Name=yfmP; OrderedLocusNames=BSU07390;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / AC327;
RX   PubMed=9141694; DOI=10.1099/00221287-143-4-1317;
RA   Yamamoto H., Uchiyama S., Nugroho F.A., Sekiguchi J.;
RT   "A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus
RT   subtilis genome.";
RL   Microbiology 143:1317-1320(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=14663075; DOI=10.1099/mic.0.26225-0;
RA   Gaballa A., Cao M., Helmann J.D.;
RT   "Two MerR homologues that affect copper induction of the Bacillus subtilis
RT   copZA operon.";
RL   Microbiology 149:3413-3421(2003).
CC   -!- FUNCTION: Repressor of the yfmOP operon. A mutation in yfmP leads to
CC       overexpression of yfmO, probably causing a decrease in cellular copper
CC       that is eventually responsible for a reduced copper induction of copZA.
CC       {ECO:0000269|PubMed:14663075}.
CC   -!- INDUCTION: YfmP is autoregulated. There is no induction with copper or
CC       other metals.
CC   -!- MISCELLANEOUS: Binds a DNA inverted repeat of the yfmPO operon.
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DR   EMBL; D86418; BAA20105.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12558.1; -; Genomic_DNA.
DR   PIR; G69813; G69813.
DR   RefSeq; NP_388620.1; NC_000964.3.
DR   RefSeq; WP_003243655.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; O06474; -.
DR   SMR; O06474; -.
DR   STRING; 224308.BSU07390; -.
DR   PaxDb; O06474; -.
DR   PRIDE; O06474; -.
DR   EnsemblBacteria; CAB12558; CAB12558; BSU_07390.
DR   GeneID; 936101; -.
DR   KEGG; bsu:BSU07390; -.
DR   PATRIC; fig|224308.179.peg.801; -.
DR   eggNOG; COG0789; Bacteria.
DR   InParanoid; O06474; -.
DR   OMA; IMELIRM; -.
DR   PhylomeDB; O06474; -.
DR   BioCyc; BSUB:BSU07390-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd04774; HTH_YfmP; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR037392; YfmP_HTH.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..140
FT                   /note="HTH-type transcriptional regulator YfmP"
FT                   /id="PRO_0000098159"
FT   DOMAIN          1..73
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   140 AA;  16503 MW;  E2BEFE283E545557 CRC64;
     MEWMKIDQVA KRSGLTKRTI RFYEEIGLIP APKRTDGGVR LYSEDDMEEL EKVISTKEVL
     GFSLQELQHF METSRQLELN KEGYLLSLDP KERKEKLEEI QETLNHQLDL IDEKIRTFQS
     FKERLQGMKG KAERAIQSIE