ID   YFP9_SCHPO              Reviewed;         274 AA.
AC   O14264;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 3.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Uncharacterized protein C7D4.09c;
GN   ORFNames=SPAC7D4.09c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB16726.2; -; Genomic_DNA.
DR   PIR; T39087; T39087.
DR   RefSeq; NP_593849.1; NM_001019278.2.
DR   AlphaFoldDB; O14264; -.
DR   SMR; O14264; -.
DR   BioGRID; 278080; 1.
DR   STRING; 4896.SPAC7D4.09c.1; -.
DR   SwissPalm; O14264; -.
DR   PaxDb; O14264; -.
DR   EnsemblFungi; SPAC7D4.09c.1; SPAC7D4.09c.1:pep; SPAC7D4.09c.
DR   PomBase; SPAC7D4.09c; -.
DR   VEuPathDB; FungiDB:SPAC7D4.09c; -.
DR   eggNOG; KOG1640; Eukaryota.
DR   HOGENOM; CLU_987498_0_0_1; -.
DR   InParanoid; O14264; -.
DR   OMA; NASHEHL; -.
DR   PhylomeDB; O14264; -.
DR   Reactome; R-SPO-193048; Androgen biosynthesis.
DR   Reactome; R-SPO-446199; Synthesis of Dolichyl-phosphate.
DR   PRO; PR:O14264; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; NAS:PomBase.
DR   GO; GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; ISO:PomBase.
DR   GO; GO:0019408; P:dolichol biosynthetic process; ISO:PomBase.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; ISO:PomBase.
DR   GO; GO:0016095; P:polyprenol catabolic process; IBA:GO_Central.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR039698; Dfg10/SRD5A3.
DR   PANTHER; PTHR14624; PTHR14624; 1.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..274
FT                   /note="Uncharacterized protein C7D4.09c"
FT                   /id="PRO_0000317696"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   274 AA;  32019 MW;  3C77D9A25AF154FB CRC64;
     MQLLNNWYSL LLTEVAAYFT STTLFVSILK NAPSLSWLMK YGGHDNFGLK PPLIATKLEV
     PKRWFWHFYA FISLLNPLFT FFILNTNFPI PIFKNIKEDL MYSKKLQVLL LIYEIHTLRR
     LYENLRFRKS GSKMLAGHYL LGYLFYTHTF LALLLCGRRS YENTMSSMQF VGLGIYAIGS
     IWQNASHEHL IAQKNHSQYL VLKKGCFKWI TGPHYLGEII VYTGIALIAQ HWLIWLVLGW
     VLCNMVAISS SYACTVKNKE QSLDFRWTLI PFLY