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YG63_SCHPO
ID   YG63_SCHPO              Reviewed;         459 AA.
AC   O60112;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Uncharacterized Rab geranylgeranyltransferase C15C4.03;
GN   ORFNames=SPBC15C4.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the Rab GDI family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA18894.1; -; Genomic_DNA.
DR   PIR; T39473; T39473.
DR   RefSeq; NP_595923.1; NM_001021831.2.
DR   AlphaFoldDB; O60112; -.
DR   SMR; O60112; -.
DR   BioGRID; 276170; 1.
DR   STRING; 4896.SPBC15C4.03.1; -.
DR   iPTMnet; O60112; -.
DR   MaxQB; O60112; -.
DR   PaxDb; O60112; -.
DR   EnsemblFungi; SPBC15C4.03.1; SPBC15C4.03.1:pep; SPBC15C4.03.
DR   GeneID; 2539612; -.
DR   KEGG; spo:SPBC15C4.03; -.
DR   PomBase; SPBC15C4.03; -.
DR   VEuPathDB; FungiDB:SPBC15C4.03; -.
DR   eggNOG; KOG1439; Eukaryota.
DR   HOGENOM; CLU_021695_3_1_1; -.
DR   InParanoid; O60112; -.
DR   OMA; IKSNICR; -.
DR   PhylomeDB; O60112; -.
DR   Reactome; R-SPO-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
DR   Reactome; R-SPO-8873719; RAB geranylgeranylation.
DR   Reactome; R-SPO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:O60112; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; IBA:GO_Central.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; ISM:PomBase.
DR   GO; GO:0018344; P:protein geranylgeranylation; IBA:GO_Central.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR018203; GDP_dissociation_inhibitor.
DR   InterPro; IPR017230; Mrs6.
DR   PANTHER; PTHR11787; PTHR11787; 1.
DR   Pfam; PF00996; GDI; 1.
DR   PIRSF; PIRSF037514; Rab_ger_ger_transf_A_fun; 1.
DR   PRINTS; PR00891; RABGDIREP.
DR   PRINTS; PR00894; YEASTMRS6P.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..459
FT                   /note="Uncharacterized Rab geranylgeranyltransferase
FT                   C15C4.03"
FT                   /id="PRO_0000317152"
SQ   SEQUENCE   459 AA;  52006 MW;  0478E52B593D7D57 CRC64;
     MDDPNSYDVI IVGTNLRNSI LSAALSWANQ RVLHIDENSF YGEIDGSLTL RDLEQINEKI
     KKVDSSQILN DNGSHKSPLK RFEVQFLNKD LIPKNKGSVI QFHPQEIFAS SELVKLLSET
     KIYKYLLLKP ARSFRLLTSN EEWIKVPESR ADIFNNKNLS LASKRIVMRF MKFVSNIADE
     QNQNLVKEWE SKPFYKFLEE VFQLSGAIEE SIIYGLCQSL SKDIPTKDAL DTVLKYFHSF
     GMYGDYSYLL AMYGTGSELC QGFCRSSAVM GGTFMLGQAI DKIDESKIVL KDGSTLSAKK
     IVSSVDEGKL PHQQIQQRYL LVKGDCQQLF QEDGFFAALD ASLIHFSPFS ISENFGNSVQ
     AKLYGSGSGD CPEGYCIWYL KTLNDSPCNE VFNLATKKLC SFSGCDDLEI IVQVDETLNQ
     LRHIDYDDTL HSAKSLFYEI LGQNNTFLQR EGLFDEDDE
 
 
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