YG76_SCHPO
ID YG76_SCHPO Reviewed; 623 AA.
AC O94674;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=AFI1-like protein C776.06c;
GN ORFNames=SPBC776.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in polarity establishment. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the AFI1/mesA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA22879.2; -; Genomic_DNA.
DR PIR; T40676; T40676.
DR RefSeq; NP_596321.2; NM_001022243.2.
DR AlphaFoldDB; O94674; -.
DR SMR; O94674; -.
DR STRING; 4896.SPBC776.06c.1; -.
DR MaxQB; O94674; -.
DR PaxDb; O94674; -.
DR EnsemblFungi; SPBC776.06c.1; SPBC776.06c.1:pep; SPBC776.06c.
DR GeneID; 2541190; -.
DR KEGG; spo:SPBC776.06c; -.
DR PomBase; SPBC776.06c; -.
DR VEuPathDB; FungiDB:SPBC776.06c; -.
DR eggNOG; ENOG502QQUZ; Eukaryota.
DR HOGENOM; CLU_009044_0_0_1; -.
DR InParanoid; O94674; -.
DR OMA; GRHFWAQ; -.
DR PRO; PR:O94674; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051666; P:actin cortical patch localization; IBA:GO_Central.
DR GO; GO:0030010; P:establishment of cell polarity; ISO:PomBase.
DR InterPro; IPR012860; Afi1_N.
DR InterPro; IPR037516; Tripartite_DENN.
DR Pfam; PF07792; Afi1; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..623
FT /note="AFI1-like protein C776.06c"
FT /id="PRO_0000374002"
FT DOMAIN 5..204
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 248..386
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 388..476
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
SQ SEQUENCE 623 AA; 71133 MW; 4DAD3395D531DB21 CRC64;
MMQIDYLLTA IFDPDRGPVL QYQCPENGEA SDLHFLAELM LPDRVHERRE DWSLFFIHFS
KKSNVFSLFS NVDDINFEPS DSNMYYVLNT IRAKRVEGTR RGGSVFAMAI CTTFPHVHAL
KPLLDTAWEI FDSSPSLKTL SMLHKSFNLH NFQSFYQKLS LDSSLILALN NFWSFFNLYL
TNSPHIMNDI INKDIDNIPK PGSELIELSR DSYNSQATFC LSAESQERYV TCVIPSIHIP
ECVGEVSISN LINTFIDGPS PFMNTDISAD INPINVLITA LLISKKVLFL TKTSSASVLA
DFVLSSCALV SGATGLLQGL TRITFPYIDL SNVESLVKLP GYLAGVMNPA FTHHADWWDV
LCDIDNQTIQ VSSNLFSDAT TTMDTKSLFN NTSPFTPISK DNQDDEIFIK DLRKFLKADD
KETLVRWRVR LYIQSFIRKA TSYEALFLES SPLNPYYKDY KFKGFGWSWD NDDEKVNELL
YLAPKFEAWR QASTYKDYCY RLHCASTPVL RCMDIQFHLD RLRNSSLSTT DAAEIFLALE
SHIRTEEDVN YLLSNCPLHS GGLSVIAFGL YHISDKVRKA VSKLLNRIET HKYGKLFYMA
LNKVDISTHV YINSQHKKKK DSF
