YGAV_ECOLI
ID YGAV_ECOLI Reviewed; 99 AA.
AC P77295;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Probable HTH-type transcriptional regulator YgaV;
GN Name=ygaV; OrderedLocusNames=b2667, JW2642;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION.
RX PubMed=18245262; DOI=10.1128/aem.02294-07;
RA Gueune H., Durand M.-J., Thouand G., DuBow M.S.;
RT "The ygaVP genes of Escherichia coli form a tributyltin-inducible operon.";
RL Appl. Environ. Microbiol. 74:1954-1958(2008).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RG Midwest center for structural genomics (MCSG);
RT "The crystal structure of the predicted DNA-binding transcriptional
RT regulator from E. coli.";
RL Submitted (JUN-2008) to the PDB data bank.
CC -!- FUNCTION: Functions as transcription repressor.
CC {ECO:0000305|PubMed:18245262}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
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DR EMBL; U00096; AAC75714.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16530.1; -; Genomic_DNA.
DR PIR; D65046; D65046.
DR RefSeq; NP_417153.1; NC_000913.3.
DR RefSeq; WP_000137280.1; NZ_STEB01000042.1.
DR PDB; 3CUO; X-ray; 2.00 A; A/B/C/D=1-99.
DR PDBsum; 3CUO; -.
DR AlphaFoldDB; P77295; -.
DR SMR; P77295; -.
DR BioGRID; 4259220; 10.
DR BioGRID; 851470; 4.
DR IntAct; P77295; 10.
DR STRING; 511145.b2667; -.
DR jPOST; P77295; -.
DR PaxDb; P77295; -.
DR PRIDE; P77295; -.
DR EnsemblBacteria; AAC75714; AAC75714; b2667.
DR EnsemblBacteria; BAA16530; BAA16530; BAA16530.
DR GeneID; 66673463; -.
DR GeneID; 947136; -.
DR KEGG; ecj:JW2642; -.
DR KEGG; eco:b2667; -.
DR PATRIC; fig|511145.12.peg.2759; -.
DR EchoBASE; EB3296; -.
DR eggNOG; COG0640; Bacteria.
DR HOGENOM; CLU_097806_6_4_6; -.
DR InParanoid; P77295; -.
DR OMA; CILANEE; -.
DR PhylomeDB; P77295; -.
DR BioCyc; EcoCyc:G7397-MON; -.
DR EvolutionaryTrace; P77295; -.
DR PRO; PR:P77295; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01022; HTH_5; 1.
DR PRINTS; PR00778; HTHARSR.
DR SMART; SM00418; HTH_ARSR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50987; HTH_ARSR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..99
FT /note="Probable HTH-type transcriptional regulator YgaV"
FT /id="PRO_0000160628"
FT DOMAIN 7..99
FT /note="HTH arsR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT DNA_BIND 41..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT HELIX 2..7
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 8..10
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 11..21
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 24..33
FT /evidence="ECO:0007829|PDB:3CUO"
FT STRAND 38..40
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 41..48
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 52..64
FT /evidence="ECO:0007829|PDB:3CUO"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:3CUO"
FT STRAND 77..81
FT /evidence="ECO:0007829|PDB:3CUO"
FT HELIX 84..97
FT /evidence="ECO:0007829|PDB:3CUO"
SQ SEQUENCE 99 AA; 10596 MW; 93B9B32C62CC0223 CRC64;
MTELAQLQAS AEQAAALLKA MSHPKRLLIL CMLSGSPGTS AGELTRITGL SASATSQHLA
RMRDEGLIDS QRDAQRILYS IKNEAVNAII ATLKNVYCP
