ID   YGB4_CUPNE              Reviewed;         260 AA.
AC   Q44015;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative hydroxypyruvate isomerase;
DE            EC=5.3.1.22;
DE   AltName: Full=Glyoxylate-induced protein;
OS   Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=106590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H16 / SK4040;
RX   PubMed=7851418; DOI=10.1111/j.1432-1033.1995.tb20358.x;
RA   Valentin H.E., Zwingmann G., Schoenebaum A., Steinbuechel A.;
RT   "Metabolic pathway for biosynthesis of poly(3-hydroxybutyrate-co-4-
RT   hydroxybutyrate) from 4-hydroxybutyrate by Alcaligenes eutrophus.";
RL   Eur. J. Biochem. 227:43-60(1995).
CC   -!- FUNCTION: Catalyzes the reversible isomerization between
CC       hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate
CC       semialdehyde). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate;
CC         Xref=Rhea:RHEA:11952, ChEBI:CHEBI:17180, ChEBI:CHEBI:57978;
CC         EC=5.3.1.22;
CC   -!- SIMILARITY: Belongs to the hyi family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L36817; AAC41420.1; -; Genomic_DNA.
DR   PIR; I39562; I39562.
DR   RefSeq; WP_010810014.1; NZ_LVWN01000023.1.
DR   AlphaFoldDB; Q44015; -.
DR   SMR; Q44015; -.
DR   GeneID; 57643657; -.
DR   GO; GO:0008903; F:hydroxypyruvate isomerase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR026040; HyI-like.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   PIRSF; PIRSF006241; HyI; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..260
FT                   /note="Putative hydroxypyruvate isomerase"
FT                   /id="PRO_0000209111"
FT   ACT_SITE        143
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
FT   ACT_SITE        240
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q9WYP7"
SQ   SEQUENCE   260 AA;  28312 MW;  6EC65F6D4DB182BF CRC64;
     MPRFAANLSM MYNEHAFLDR FAAAAADGFR AVEFLFPYEH AAAELRARLD ANGLTQALFN
     AAPGDWAAGE RGLAALPGRE ADFRGTIGRA LEYAGVIGND RIHVMAGLIP ADADRARCRA
     TYLENLAFAA NAAAAQGVTV LIEPINTRDM PGYFLNRQDD GQAICKEVGA ANLKVQFDCY
     HCQIVEGDVA MKLKRDIAGI GHIQIAGVPE RHEPDVGELN YPYLFEVMDT LGYDGWIGCE
     YRPRAGTSAG LGWLKPYLGR