YGCC1_PLAF7
ID YGCC1_PLAF7 Reviewed; 1139 AA.
AC O97237;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 3.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=GRIP and coiled-coil domain-containing protein;
GN ORFNames=PF3D7_0305200, PFC0235w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000312|EMBL:CAB39003.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [4] {ECO:0000305}
RP SYNTHESIS OF 798-837, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844502; CAB39003.3; -; Genomic_DNA.
DR RefSeq; XP_001351128.1; XM_001351092.1.
DR AlphaFoldDB; O97237; -.
DR SMR; O97237; -.
DR BioGRID; 1209621; 5.
DR IntAct; O97237; 6.
DR STRING; 5833.PFC0235w; -.
DR PRIDE; O97237; -.
DR EnsemblProtists; CAB39003; CAB39003; PF3D7_0305200.
DR GeneID; 814370; -.
DR KEGG; pfa:PF3D7_0305200; -.
DR HOGENOM; CLU_278062_0_0_1; -.
DR InParanoid; O97237; -.
DR OMA; DYDNIKS; -.
DR PhylomeDB; O97237; -.
DR Proteomes; UP000001450; Chromosome 3.
DR InterPro; IPR000237; GRIP_dom.
DR PROSITE; PS50913; GRIP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Reference proteome.
FT CHAIN 1..1139
FT /note="GRIP and coiled-coil domain-containing protein"
FT /id="PRO_0000364021"
FT DOMAIN 1084..1135
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 366..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 472..648
FT /evidence="ECO:0000255"
FT COILED 758..877
FT /evidence="ECO:0000255"
FT COILED 1043..1084
FT /evidence="ECO:0000255"
FT COMPBIAS 366..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 135795 MW; 8919CC04E41530B9 CRC64;
MNFCDNNEMN ETKNFMMSNK NDDIVVDCDE YIDGNVFEKN TNMGNIYDEN YNVDMKNDNL
LSKLNDNISF TYTTNGQVEK QENEIKEKQN ILHYQIYIDN DEDKYKYCSN SNLHKNEEEH
EKGSPNNIYE ELDNNLEKKY FYYNSDSKHC IDEKNETNDL ENENVVTSMD VSYENVLNDN
FIKSRSTSIN YTDNSFVLNK ENLKSSHHIN GYYINDHDNI KSDIINDHDN IKSDIINDYD
NIKGDKINEY DNIKSDKIND YDNIKSDIIN DYDNIKSDKI NDYDNIKSDK INDYDNIKSD
KINDYDNIKS DKINDYDNIK SDKINHYDNI KSDKINDYDN IKSDKINDYD NIKSDKINDY
DNIKYNDDSQ INNNVSNKVN SPDDDPNTYE KDKKDIINCN IYEENKNNMN NIIHNDKENI
HMVDTGKNEE NNNIDNKNND DINKVNVLTR VDTENYILNE ENILPLHTND DVTKLLDEIN
DLKNTIENMK KEKINLLSKF KAYTLNNKKE LEELKIKCKN KEEQIKMYEN KLQNKEDEIM
NYVNEIQNKD KKIESYHIKL HNKEEEIMNY VNEIQNKEEE IIKYVNELQN SDVQKEKKEL
KTINEVLKNT NEKLEKEITS LLGEMKKIEE ENKVLKIFKE EKNKINNEKV TQIKGDDIND
DNDMKFKQIL LDNKTFNKLL VNELNIVEEN ILFCFSIDKD KNRLLVCIKQ NDDNFFVIPN
CIFDEKFPGL QKKTESMIIQ DIHEKEILEL KNKQMNELYI LKKEKEDIYK EYEEYKKKVT
SLINETNYNY KNIEEKENEI KELNNTLNKY KEEMNNYKEE IIVINEKYKL LEIELCKEKN
IRDQQNVGIS DLKKKMLKEK IELEKKYKEQ YEKETQQKIN DMKIIFDNKE KILQDQIDDL
LHKIEKLTFS NDEKTKTIEN LQIYMDNDDN IMNQEGIQKN EKKQIIDNPI NTDEKDLLNY
IPDNHINSDL NHINSNVEND YVEKRNKNNV HLSKKETNYQ HNINEQENDN NNNNNNNNNN
NNVEKLKSIN STNTSIPIYP YEYKKIRKKL ETYEILLNEQ QEGKKKMTEE INSLKNQVKN
YESINGNYQH IIYQKNILSN FIAQIPSRIQ VDDYVSVIFN SFNFSNQEIE AINIKRSKK
