YGCS_ECOLI
ID YGCS_ECOLI Reviewed; 445 AA.
AC Q46909; Q2MA58;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Inner membrane metabolite transport protein YgcS;
GN Name=ygcS; OrderedLocusNames=b2771, JW5845;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA69281.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U29579; AAA69281.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC75813.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE76848.1; -; Genomic_DNA.
DR PIR; G65058; G65058.
DR RefSeq; NP_417251.2; NC_000913.3.
DR RefSeq; WP_001098105.1; NZ_CP047127.1.
DR AlphaFoldDB; Q46909; -.
DR SMR; Q46909; -.
DR BioGRID; 4260743; 160.
DR STRING; 511145.b2771; -.
DR TCDB; 2.A.1.1.95; the major facilitator superfamily (mfs).
DR PaxDb; Q46909; -.
DR PRIDE; Q46909; -.
DR EnsemblBacteria; AAC75813; AAC75813; b2771.
DR EnsemblBacteria; BAE76848; BAE76848; BAE76848.
DR GeneID; 947238; -.
DR KEGG; ecj:JW5845; -.
DR KEGG; eco:b2771; -.
DR PATRIC; fig|511145.12.peg.2869; -.
DR EchoBASE; EB2927; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_46_6_6; -.
DR InParanoid; Q46909; -.
DR OMA; QIWIIWL; -.
DR PhylomeDB; Q46909; -.
DR BioCyc; EcoCyc:B2771-MON; -.
DR PRO; PR:Q46909; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..445
FT /note="Inner membrane metabolite transport protein YgcS"
FT /id="PRO_0000050483"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..56
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..114
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..175
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..286
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..337
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..400
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..445
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 445 AA; 48234 MW; B59E452721B15774 CRC64;
MNTSPVRMDD LPLNRFHCRI AALTFGAHLT DGYVLGVIGY AIIQLTPAMQ LTPFMAGMIG
GSALLGLFLG SLVLGWISDH IGRQKIFTFS FLLITLASFL QFFATTPEHL IGLRILIGIG
LGGDYSVGHT LLAEFSPRRH RGILLGAFSV VWTVGYVLAS IAGHHFISEN PEAWRWLLAS
AALPALLITL LRWGTPESPR WLLRQGRFAE AHAIVHRYFG PHVLLGDEVV TATHKHIKTL
FSSRYWRRTA FNSVFFVCLV IPWFVIYTWL PTIAQTIGLE DALTASLMLN ALLIVGALLG
LVLTHLLAHR KFLLGSFLLL AATLVVMACL PSGSSLTLLL FVLFSTTISA VSNLVGILPA
ESFPTDIRSL GVGFATAMSR LGAAVSTGLL PWVLAQWGMQ VTLLLLATVL LVGFVVTWLW
APETKALPLV AAGNVGGANE HSVSV
