YGCW_ECOLI
ID YGCW_ECOLI Reviewed; 261 AA.
AC P76633; P78216; Q46913;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Uncharacterized oxidoreductase YgcW;
DE EC=1.-.-.-;
GN Name=ygcW; OrderedLocusNames=b2774, JW5443;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-117.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA69285.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U29579; AAA69285.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC75816.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16569.2; -; Genomic_DNA.
DR PIR; B65059; B65059.
DR RefSeq; NP_417254.4; NC_000913.3.
DR RefSeq; WP_000021334.1; NZ_LN832404.1.
DR AlphaFoldDB; P76633; -.
DR SMR; P76633; -.
DR BioGRID; 4260745; 11.
DR STRING; 511145.b2774; -.
DR PaxDb; P76633; -.
DR PRIDE; P76633; -.
DR EnsemblBacteria; AAC75816; AAC75816; b2774.
DR EnsemblBacteria; BAA16569; BAA16569; BAA16569.
DR GeneID; 947232; -.
DR KEGG; ecj:JW5443; -.
DR KEGG; eco:b2774; -.
DR PATRIC; fig|1411691.4.peg.3964; -.
DR EchoBASE; EB2930; -.
DR eggNOG; COG1028; Bacteria.
DR HOGENOM; CLU_010194_1_1_6; -.
DR InParanoid; P76633; -.
DR OMA; QHGKIDN; -.
DR PhylomeDB; P76633; -.
DR BioCyc; EcoCyc:G7440-MON; -.
DR PRO; PR:P76633; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..261
FT /note="Uncharacterized oxidoreductase YgcW"
FT /id="PRO_0000054835"
FT ACT_SITE 166
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 22..46
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 153
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 261 AA; 28042 MW; 2D6B2382768A4F7E CRC64;
MSIESLNAFS MDFFSLKGKT AIVTGGNSGL GQAFAMALAK AGANIFIPSF VKDNGETKEM
IEKQGVEVDF MQVGITAEGA PQKIIAACCE RFGTVDILVN NAGICKLNKV LDFGRADWDP
MIDVNLTAAF ELSYEAAKIM IPQKSGKIIN ICSLFSYLGG QWSPAYSATK HALAGFTKAY
CDELGQYNIQ VNGIAPGYYA TDITLATRSN PETNQRVLDH IPANRWGDTQ DLMGAAVFLA
SPASNYVNGH LLVVDGGYLV R
