YGD4_SCHPO
ID YGD4_SCHPO Reviewed; 336 AA.
AC O94563;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Putative uncharacterized oxidoreductase C1773.04;
DE EC=1.1.1.-;
DE Flags: Precursor;
GN ORFNames=SPBC1773.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-153, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAA21909.1; -; Genomic_DNA.
DR PIR; T39669; T39669.
DR RefSeq; NP_595119.1; NM_001021026.2.
DR AlphaFoldDB; O94563; -.
DR SMR; O94563; -.
DR BioGRID; 276287; 4.
DR STRING; 4896.SPBC1773.04.1; -.
DR iPTMnet; O94563; -.
DR MaxQB; O94563; -.
DR PaxDb; O94563; -.
DR PRIDE; O94563; -.
DR EnsemblFungi; SPBC1773.04.1; SPBC1773.04.1:pep; SPBC1773.04.
DR GeneID; 2539735; -.
DR KEGG; spo:SPBC1773.04; -.
DR PomBase; SPBC1773.04; -.
DR VEuPathDB; FungiDB:SPBC1773.04; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR InParanoid; O94563; -.
DR OMA; IIATDPQ; -.
DR PhylomeDB; O94563; -.
DR PRO; PR:O94563; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0043892; F:methylglyoxal reductase (NADPH-dependent) activity; ISO:PomBase.
DR GO; GO:0140041; P:cellular detoxification of methylglyoxal; IC:PomBase.
DR GO; GO:0061727; P:methylglyoxal catabolic process to lactate; IC:PomBase.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase; Phosphoprotein; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..336
FT /note="Putative uncharacterized oxidoreductase C1773.04"
FT /id="PRO_0000316222"
FT BINDING 38
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:A0A059TC02"
FT BINDING 167
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:A0A059TC02"
FT MOD_RES 153
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 336 AA; 37806 MW; 9E5FA4361367D876 CRC64;
MSELVLITGI TGFVASHSAE ALLSQGYRVR GTYRFQEKLD GLLKNRPEWE KKVEFVQVPD
CRAPNAYVEA AKGVDYVIHA ATEVHSNLEP PRKDPHELLH IAIQGCENAL IAAAQEPKVK
RFVYISSEAA LKGPVNYFGD GHVFTEKDWN PKTLREAEES DDELLNYTVC KKLGERAMHA
FVARNTPRFQ AIALNPPLIL GPVFHLQSVD NLNFSTWFFW QLIKGRYEVA PESKFFNYVD
VRDLAEAQVK ALTAKTDKDR FVISGGAFKN DDIVNVALKY FPQFKDKIAK PNGETSPCNY
EVDASLSIKE LGLTYRPAEE TFKDATESLY KLAGLL
