YGDD_ECOLI
ID YGDD_ECOLI Reviewed; 131 AA.
AC P0ADR2; P32065; Q2MA27; Q46667;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=UPF0382 inner membrane protein YgdD;
GN Name=ygdD; OrderedLocusNames=b2807, JW2778;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=8188587; DOI=10.1128/jb.176.10.2862-2868.1994;
RA Wilson R.L., Stauffer G.V.;
RT "DNA sequence and characterization of GcvA, a LysR family regulatory
RT protein for the Escherichia coli glycine cleavage enzyme system.";
RL J. Bacteriol. 176:2862-2868(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=7704273; DOI=10.1099/13500872-141-2-419;
RA Everett M.J., Walsh T., Guay G., Bennett P.M.;
RT "GcvA, a LysR-type transcriptional regulator protein, activates expression
RT of the cloned Citrobacter freundii ampC beta-lactamase gene in Escherichia
RT coli: cross-talk between DNA-binding proteins.";
RL Microbiology 141:419-430(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / BW25113;
RX PubMed=26860543; DOI=10.1099/mic.0.000249;
RA Paulsen V.S., Mardirossian M., Blencke H.M., Benincasa M., Runti G.,
RA Nepa M., Haug T., Stensvaag K., Scocchi M.;
RT "Inner membrane proteins YgdD and SbmA are required for the complete
RT susceptibility of Escherichia coli to the proline-rich antimicrobial
RT peptide arasin 1(1-25).";
RL Microbiology 162:601-609(2016).
CC -!- FUNCTION: May be a peptide transporter or a protein that facilitates
CC peptide internalization (PubMed:26860543).
CC {ECO:0000305|PubMed:26860543}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- DISRUPTION PHENOTYPE: Mutants show a slight decrease in the
CC internalization level of some proline-rich antimicrobial peptides of
CC eukaryotic origin. {ECO:0000269|PubMed:26860543}.
CC -!- SIMILARITY: Belongs to the UPF0382 family. {ECO:0000305}.
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DR EMBL; U01030; AAC13743.1; -; Genomic_DNA.
DR EMBL; X73413; CAA51814.1; -; Genomic_DNA.
DR EMBL; U29581; AAB40457.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75849.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76879.1; -; Genomic_DNA.
DR PIR; I41066; I41066.
DR RefSeq; NP_417287.1; NC_000913.3.
DR RefSeq; WP_000203905.1; NZ_STEB01000030.1.
DR AlphaFoldDB; P0ADR2; -.
DR BioGRID; 4260934; 30.
DR STRING; 511145.b2807; -.
DR PaxDb; P0ADR2; -.
DR DNASU; 947279; -.
DR EnsemblBacteria; AAC75849; AAC75849; b2807.
DR EnsemblBacteria; BAE76879; BAE76879; BAE76879.
DR GeneID; 66673326; -.
DR GeneID; 947279; -.
DR KEGG; ecj:JW2778; -.
DR KEGG; eco:b2807; -.
DR PATRIC; fig|1411691.4.peg.3926; -.
DR EchoBASE; EB1741; -.
DR eggNOG; COG2363; Bacteria.
DR HOGENOM; CLU_096548_3_2_6; -.
DR InParanoid; P0ADR2; -.
DR OMA; QFYHTFA; -.
DR PhylomeDB; P0ADR2; -.
DR BioCyc; EcoCyc:EG11793-MON; -.
DR PRO; PR:P0ADR2; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR006696; DUF423.
DR PANTHER; PTHR43461; PTHR43461; 1.
DR Pfam; PF04241; DUF423; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..131
FT /note="UPF0382 inner membrane protein YgdD"
FT /id="PRO_0000169329"
FT TOPO_DOM 1..4
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..97
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 34
FT /note="A -> G (in Ref. 1; AAC13743)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 14333 MW; 2EE9FD9B596012DD CRC64;
MTSRFMLIFA AISGFIFVAL GAFGAHVLSK TMGAVEMGWI QTGLEYQAFH TLAILGLAVA
MQRRISIWFY WSSVFLALGT VLFSGSLYCL ALSHLRLWAF VTPVGGVSFL AGWALMLVGA
IRLKRKGVSH E
