CBH2_SCHPO
ID CBH2_SCHPO Reviewed; 514 AA.
AC O60108;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=CENP-B homolog protein 2;
DE Short=CBHP-2;
GN Name=cbh2; ORFNames=SPBC14F5.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11238404; DOI=10.1093/genetics/157.3.1191;
RA Irelan J.T., Gutkin G.I., Clarke L.;
RT "Functional redundancies, distinct localizations and interactions among
RT three fission yeast homologs of centromere protein-B.";
RL Genetics 157:1191-1203(2001).
CC -!- FUNCTION: Binds to the central core and core-associated repeat regions
CC of centromeric heterochromatin. {ECO:0000269|PubMed:11238404}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00583,
CC ECO:0000269|PubMed:11238404}. Chromosome, centromere
CC {ECO:0000269|PubMed:11238404}.
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DR EMBL; CU329671; CAA19330.1; -; Genomic_DNA.
DR PIR; T39458; T39458.
DR RefSeq; NP_596738.1; NM_001022664.2.
DR AlphaFoldDB; O60108; -.
DR SMR; O60108; -.
DR BioGRID; 276280; 35.
DR IntAct; O60108; 2.
DR STRING; 4896.SPBC14F5.12c.1; -.
DR iPTMnet; O60108; -.
DR MaxQB; O60108; -.
DR PaxDb; O60108; -.
DR PRIDE; O60108; -.
DR EnsemblFungi; SPBC14F5.12c.1; SPBC14F5.12c.1:pep; SPBC14F5.12c.
DR GeneID; 2539728; -.
DR KEGG; spo:SPBC14F5.12c; -.
DR PomBase; SPBC14F5.12c; cbh2.
DR VEuPathDB; FungiDB:SPBC14F5.12c; -.
DR eggNOG; KOG3105; Eukaryota.
DR HOGENOM; CLU_018294_0_3_1; -.
DR InParanoid; O60108; -.
DR OMA; QWMQKLD; -.
DR PhylomeDB; O60108; -.
DR PRO; PR:O60108; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; NAS:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019237; F:centromeric DNA binding; TAS:PomBase.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; TAS:PomBase.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR041188; HTH_ABP1_N.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF18107; HTH_ABP1_N; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
PE 3: Inferred from homology;
KW Centromere; Chromosome; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..514
FT /note="CENP-B homolog protein 2"
FT /id="PRO_0000126135"
FT DOMAIN 70..145
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 172..384
FT /note="DDE-1"
FT /evidence="ECO:0000255"
SQ SEQUENCE 514 AA; 59691 MW; 871837EEC66F1F30 CRC64;
MPPLRRQALT LAEKKAIRKH YFESATKPSQ QELISWFEEH FHKKLAQSTV SSILSSKNEF
LDNLDAENSQ IRRNRQGKYP ILENALIDWQ TRLQKQDGAI TGNAIKKSAA ELWRRIPEYS
ELPIPEFSNG WLEKFKKRCL KHGLKLQGES TSVNQGTYEE NMVQIQELIS LFDPKDIFNM
DETGLCWKLI PNQSPASERV KGITRDKARV TVTICCNATG SEKAPLWVIG YAKSPRAFRQ
ANAHPDSMDF HWRYNGTARM TTSIMEEWLR WFDDLMKGRK VLLILDKFVA HECALENIRN
SERKLVNTTV VFLPVNSTEI YHPCGQEIVY AFKSYYRKYW LNYMLEEIRL GKNPSKTMNV
LKAVRWMIRS WNVDFEPSII YNCFLRSGLF QNQQPLTGPS PETIRIAVNL QELIGKYLGD
KDIFQIENFI NPIEENSADT NDDIVNQVAA QFLDEREFET DEEEEESQYL LSTKDAINAI
NTLLNFQEQS EDGNVLFTRT LLQFQKVLES RSIV
