ID   YGER_ECOLI              Reviewed;         251 AA.
AC   Q46798; Q2M9X5;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Uncharacterized lipoprotein YgeR;
DE   Flags: Precursor;
GN   Name=ygeR; OrderedLocusNames=b2865, JW2833;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   POSSIBLE SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / MG1655 / TB28;
RX   PubMed=19525345; DOI=10.1128/jb.00505-09;
RA   Uehara T., Dinh T., Bernhardt T.G.;
RT   "LytM-domain factors are required for daughter cell separation and rapid
RT   ampicillin-induced lysis in Escherichia coli.";
RL   J. Bacteriol. 191:5094-5107(2009).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Slightly enriched at the
CC       septal ring.
CC   -!- DISRUPTION PHENOTYPE: Cells are shorter in a single mutant, while
CC       triple envC-nlpD-ygeR disruptions have defects in septation and cell
CC       separation and form long filaments (15-fold longer) and further yet by
CC       the quadruple disruption mutant (envC-nlpD-mepM(yebA)-ygeR, over 21-
CC       fold longer). Quadruple mutants are less sensitive to ampicillin lysis.
CC       {ECO:0000269|PubMed:19525345}.
CC   -!- SIMILARITY: Belongs to the peptidase M23B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA83046.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U28375; AAA83046.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC75903.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76931.1; -; Genomic_DNA.
DR   PIR; A65070; A65070.
DR   RefSeq; NP_417341.4; NC_000913.3.
DR   RefSeq; WP_001301085.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q46798; -.
DR   SMR; Q46798; -.
DR   BioGRID; 4262318; 185.
DR   DIP; DIP-36034N; -.
DR   IntAct; Q46798; 5.
DR   STRING; 511145.b2865; -.
DR   jPOST; Q46798; -.
DR   PaxDb; Q46798; -.
DR   PRIDE; Q46798; -.
DR   EnsemblBacteria; AAC75903; AAC75903; b2865.
DR   EnsemblBacteria; BAE76931; BAE76931; BAE76931.
DR   GeneID; 947352; -.
DR   KEGG; ecj:JW2833; -.
DR   KEGG; eco:b2865; -.
DR   PATRIC; fig|511145.12.peg.2958; -.
DR   EchoBASE; EB2860; -.
DR   eggNOG; COG4942; Bacteria.
DR   HOGENOM; CLU_029425_0_4_6; -.
DR   InParanoid; Q46798; -.
DR   OMA; WTWPANG; -.
DR   PhylomeDB; Q46798; -.
DR   BioCyc; EcoCyc:G7484-MON; -.
DR   PRO; PR:Q46798; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0000920; P:septum digestion after cytokinesis; IBA:GO_Central.
DR   CDD; cd00118; LysM; 1.
DR   Gene3D; 2.70.70.10; -; 1.
DR   Gene3D; 3.10.350.10; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR018392; LysM_dom.
DR   InterPro; IPR036779; LysM_dom_sf.
DR   InterPro; IPR016047; Peptidase_M23.
DR   Pfam; PF01476; LysM; 1.
DR   Pfam; PF01551; Peptidase_M23; 1.
DR   SMART; SM00257; LysM; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   PROSITE; PS51782; LYSM; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..251
FT                   /note="Uncharacterized lipoprotein YgeR"
FT                   /id="PRO_0000013776"
FT   DOMAIN          40..84
FT                   /note="LysM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT   REGION          93..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   251 AA;  26565 MW;  FCD6235D39790475 CRC64;
     MSAGRLNKKS LGIVMLLSVG LLLAGCSGSK SSDTGTYSGS VYTVKRGDTL YRISRTTGTS
     VKELARLNGI SPPYTIEVGQ KLKLGGAKSS SITRKSTAKS TTKTASVTPS SAVPKSSWPP
     VGQRCWLWPT TGKVIMPYST ADGGNKGIDI SAPRGTPIYA AGAGKVVYVG NQLRGYGNLI
     MIKHSEDYIT AYAHNDTMLV NNGQSVKAGQ KIATMGSTDA ASVRLHFQIR YRATAIDPLR
     YLPPQGSKPK C