ID   YGFF_ECOLI              Reviewed;         247 AA.
AC   P52037; P77138; Q2M9T9; Q46830;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Uncharacterized oxidoreductase YgfF;
DE            EC=1.-.-.-;
GN   Name=ygfF; Synonyms=yqfD; OrderedLocusNames=b2902, JW2870;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=7764507; DOI=10.1271/bbb.58.117;
RA   Talukder A.A., Yanai S., Yamada M.;
RT   "Analysis of products of the Escherichia coli genomic genes and regulation
RT   of their expressions: an applicable procedure for genomic analysis of other
RT   microorganisms.";
RL   Biosci. Biotechnol. Biochem. 58:117-120(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 137-197.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       P52037; P0A9P0: lpdA; NbExp=2; IntAct=EBI-561028, EBI-542856;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; U28377; AAA69070.1; -; Genomic_DNA.
DR   EMBL; U28375; AAA83083.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75940.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76967.1; -; Genomic_DNA.
DR   EMBL; D21144; BAA04680.1; -; Genomic_DNA.
DR   EMBL; U83189; AAB40290.1; -; Genomic_DNA.
DR   PIR; F65074; F65074.
DR   RefSeq; NP_417378.1; NC_000913.3.
DR   RefSeq; WP_000951964.1; NZ_SSUV01000019.1.
DR   AlphaFoldDB; P52037; -.
DR   SMR; P52037; -.
DR   BioGRID; 4260859; 2.
DR   DIP; DIP-12165N; -.
DR   IntAct; P52037; 3.
DR   STRING; 511145.b2902; -.
DR   jPOST; P52037; -.
DR   PaxDb; P52037; -.
DR   PRIDE; P52037; -.
DR   EnsemblBacteria; AAC75940; AAC75940; b2902.
DR   EnsemblBacteria; BAE76967; BAE76967; BAE76967.
DR   GeneID; 66673224; -.
DR   GeneID; 947373; -.
DR   KEGG; ecj:JW2870; -.
DR   KEGG; eco:b2902; -.
DR   PATRIC; fig|1411691.4.peg.3830; -.
DR   EchoBASE; EB2798; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_3_6; -.
DR   InParanoid; P52037; -.
DR   OMA; HEHQPRV; -.
DR   PhylomeDB; P52037; -.
DR   BioCyc; EcoCyc:G7514-MON; -.
DR   PRO; PR:P52037; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Uncharacterized oxidoreductase YgfF"
FT                   /id="PRO_0000054836"
FT   ACT_SITE        156
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         4..28
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   247 AA;  25938 MW;  8F17257B5905E4F9 CRC64;
     MAIALVTGGS RGIGRATALL LAQEGYTVAV NYQQNLHAAQ EVMNLITQAG GKAFVLQADI
     SDENQVVAMF TAIDQHDEPL AALVNNAGIL FTQCTVENLT AERINRVLST NVTGYFLCCR
     EAVKRMALKN GGSGGAIVNV SSVASRLGSP GEYVDYAASK GAIDTLTTGL SLEVAAQGIR
     VNCVRPGFIY TEMHASGGEP GRVDRVKSNI PMQRGGQAEE VAQAIVWLLS DKASYVTGSF
     IDLAGGK