ID   YGHD_ECOLI              Reviewed;         178 AA.
AC   Q46832; Q2M9M6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative type II secretion system M-type protein YghD;
DE            Short=Putative T2SS M-type protein YghD;
DE   AltName: Full=Putative extracytoplasmic function protein C;
DE   AltName: Full=Putative general secretion pathway M-type protein YghD;
GN   Name=yghD; Synonyms=ecfC; OrderedLocusNames=b2968, JW2935;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Involved in a type II secretion system (T2SS, formerly
CC       general secretion pathway, GSP) for the export of folded proteins
CC       across the outer membrane. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: In many other E.coli strains this gene is part of a type
CC       II secretion system, but in MG1655 the locus is missing a number of
CC       genes. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP M family. {ECO:0000305}.
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DR   EMBL; U28377; AAA69135.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76004.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77030.1; -; Genomic_DNA.
DR   PIR; F65082; F65082.
DR   RefSeq; NP_417442.1; NC_000913.3.
DR   RefSeq; WP_000942785.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q46832; -.
DR   SMR; Q46832; -.
DR   BioGRID; 4262353; 1187.
DR   STRING; 511145.b2968; -.
DR   PaxDb; Q46832; -.
DR   PRIDE; Q46832; -.
DR   EnsemblBacteria; AAC76004; AAC76004; b2968.
DR   EnsemblBacteria; BAE77030; BAE77030; BAE77030.
DR   GeneID; 947025; -.
DR   KEGG; ecj:JW2935; -.
DR   KEGG; eco:b2968; -.
DR   PATRIC; fig|1411691.4.peg.3763; -.
DR   EchoBASE; EB2812; -.
DR   eggNOG; COG3149; Bacteria.
DR   HOGENOM; CLU_118900_3_0_6; -.
DR   InParanoid; Q46832; -.
DR   OMA; PQGNKIQ; -.
DR   BioCyc; EcoCyc:G7535-MON; -.
DR   PRO; PR:Q46832; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR   InterPro; IPR007690; T2SS_GspM.
DR   InterPro; IPR023229; T2SS_M_periplasmic_sf.
DR   Pfam; PF04612; T2SSM; 1.
DR   PIRSF; PIRSF006291; GspM; 1.
DR   SUPFAM; SSF103054; SSF103054; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..178
FT                   /note="Putative type II secretion system M-type protein
FT                   YghD"
FT                   /id="PRO_0000207329"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..178
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  20395 MW;  18822CED9B5BF022 CRC64;
     MLRDKFIHYF QQWRERQLSR GEHWLAQHLA GRSPREKGML LAAVVFLFSV GYYVLIWQPL
     SERIEQQETI LQQLVAMNTR LKNAAPDIIA ARKSATTTPA QVSRVISDSA SAHSVVIRRI
     ADRGENIQVW IEPVVFNDLL KWLNALDEKY ALRVTQIDVS AAEKPGMVNV QRLEFGRG