ID   YGHE_ECOLI              Reviewed;         286 AA.
AC   Q46833;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Putative type II secretion system L-type protein YghE;
DE   AltName: Full=Putative general secretion pathway L-type protein YghE;
GN   Name=yghE; OrderedLocusNames=b2969;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   IDENTIFICATION, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=30837344; DOI=10.1128/mbio.02819-18;
RA   Weaver J., Mohammad F., Buskirk A.R., Storz G.;
RT   "Identifying small proteins by ribosome profiling with stalled initiation
RT   complexes.";
RL   MBio 10:0-0(2019).
CC   -!- FUNCTION: Involved in a type II secretion system (T2SS, formerly
CC       general secretion pathway, GSP) for the export of folded proteins
CC       across the outer membrane. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}.
CC   -!- INDUCTION: Expressed at low levels in exponential phase in rich medium
CC       (at protein level). {ECO:0000269|PubMed:30837344}.
CC   -!- MISCELLANEOUS: In many other E.coli strains this gene is part of a type
CC       II secretion system, but in MG1655 the locus is missing a number of
CC       genes. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP L family. {ECO:0000305}.
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DR   EMBL; U28377; AAA69136.1; -; Genomic_DNA.
DR   EMBL; U00096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; G65082; G65082.
DR   AlphaFoldDB; Q46833; -.
DR   SMR; Q46833; -.
DR   DIP; DIP-12203N; -.
DR   IntAct; Q46833; 1.
DR   PRIDE; Q46833; -.
DR   PATRIC; fig|83333.103.peg.3867; -.
DR   EchoBASE; EB2813; -.
DR   PhylomeDB; Q46833; -.
DR   BioCyc; EcoCyc:G7536-MON; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR   InterPro; IPR025691; GspL_pp_dom.
DR   InterPro; IPR007812; T2SS_protein-GspL.
DR   Pfam; PF12693; GspL_C; 1.
DR   TIGRFAMs; TIGR01709; typeII_sec_gspL; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..286
FT                   /note="Putative type II secretion system L-type protein
FT                   YghE"
FT                   /id="PRO_0000207321"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   286 AA;  32058 MW;  15305711D0597FCA CRC64;
     MIHQQHMRNI AQWLQENGIT RATVAPDWMS IPCGFMACDA QRVICRIDEC RGWSAGLALA
     PVMFRAQLNE QDLPLSLTVV GIAPEKLSAW AGADAERLTV TALPAITTYG EPEGNLLTGP
     WQPRVSYRKQ WARWRVMILP ILLILVALAV ERGVTLWSVS EQVAQSRTQA EEQFLTLFPE
     QKRIVNLRSQ VTMALKKYRP QADDTRLLAE LSAIASTLKS ASLSDIEMRG FTFDQKRQIL
     HLQLRAANFA SFDKLRSVLA TDYVVQQDAL QKEGDAVSGG VTLRRK