YGIQ_ECOLI
ID YGIQ_ECOLI Reviewed; 739 AA.
AC Q46861; Q2M9I4; Q46862; Q6BF53;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=UPF0313 protein YgiQ;
GN Name=ygiQ; Synonyms=ygiR; OrderedLocusNames=b4469, JW5501;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000305};
CC -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA69183.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAA69184.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U28377; AAA69183.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U28377; AAA69184.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAT48161.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77072.1; -; Genomic_DNA.
DR RefSeq; WP_000095187.1; NZ_STEB01000001.1.
DR RefSeq; YP_026196.1; NC_000913.3.
DR AlphaFoldDB; Q46861; -.
DR BioGRID; 4260933; 21.
DR DIP; DIP-12224N; -.
DR IntAct; Q46861; 2.
DR STRING; 511145.b4469; -.
DR PaxDb; Q46861; -.
DR PRIDE; Q46861; -.
DR EnsemblBacteria; AAT48161; AAT48161; b4469.
DR EnsemblBacteria; BAE77072; BAE77072; BAE77072.
DR GeneID; 66673090; -.
DR GeneID; 948963; -.
DR KEGG; ecj:JW5501; -.
DR KEGG; eco:b4469; -.
DR PATRIC; fig|1411691.4.peg.3714; -.
DR EchoBASE; EB2838; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_018288_2_0_6; -.
DR InParanoid; Q46861; -.
DR OMA; TCMYYTG; -.
DR PhylomeDB; Q46861; -.
DR BioCyc; EcoCyc:G7568-MON; -.
DR PRO; PR:Q46861; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.30.20; -; 1.
DR HAMAP; MF_01251; UPF0313; 1.
DR InterPro; IPR006638; Elp3/MiaB/NifB.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR022946; UPF0313.
DR InterPro; IPR024560; UPF0313_C.
DR InterPro; IPR013704; UPF0313_N.
DR PANTHER; PTHR32331; PTHR32331; 1.
DR Pfam; PF11842; DUF3362; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF08497; Radical_SAM_N; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01069; UPF0313; 1.
DR SMART; SM00729; Elp3; 1.
DR TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW S-adenosyl-L-methionine.
FT CHAIN 1..739
FT /note="UPF0313 protein YgiQ"
FT /id="PRO_0000076383"
FT DOMAIN 372..650
FT /note="Radical SAM core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT REGION 685..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 386
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 390
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
FT BINDING 393
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255"
SQ SEQUENCE 739 AA; 83478 MW; F85248757612026B CRC64;
MSSISLIQPD RDLFSWPQYW AACFGPAPFL PMSREEMDQL GWDSCDIILV TGDAYVDHPS
FGMAICGRML EAQGFRVGII AQPDWSSKDD FMRLGKPNLF FGVTAGNMDS MINRYTADRR
LRHDDAYTPD NVAGKRPDRA TLVYTQRCKE AWKDVPVILG GIEASLRRTA HYDYWSDTVR
RSVLVDSKAD MLMFGNGERP LVEVAHRLAM GEPISEIRDV RNTAIIVKEA LPGWSGVDST
RLDTPGKIDP IPHPYGEDLP CADNKPVAPK KQEAKAVTVQ PPRPKPWEKT YVLLPSFEKV
KGDKVLYAHA SRILHHETNP GCARALMQKH GDRYVWINPP AIPLSTEEMD SVFALPYKRV
PHPAYGNARI PAYEMIRFSV NIMRGCFGGC SFCSITEHEG RIIQSRSEDS IINEIEAIRD
TVPGFTGVIS DLGGPTANMY MLRCKSPRAE QTCRRLSCVY PDICPHMDTN HEPTINLYRR
ARDLKGIKKI LIASGVRYDI AVEDPRYIKE LATHHVGGYL KIAPEHTEEG PLSKMMKPGM
GSYDRFKELF DTYSKQAGKE QYLIPYFISA HPGTRDEDMV NLALWLKKHR FRLDQVQNFY
PSPLANSTTM YYTGKNPLAK IGYKSEDVFV PKGDKQRRLH KALLRYHDPA NWPLIRQALE
AMGKKHLIGS RRDCLVPAPT IEEMREARRQ NRNTRPALTK HTPMATQRQT PATAKKASST
QSRPVNAGAK KRPKAAVGR
