YGIQ_SHIFL
ID YGIQ_SHIFL Reviewed; 739 AA.
AC Q83JL2; Q7UBJ9;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=UPF0313 protein YgiQ {ECO:0000255|HAMAP-Rule:MF_01251};
GN Name=ygiQ {ECO:0000255|HAMAP-Rule:MF_01251};
GN OrderedLocusNames=SF3060, S3263;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01251};
CC Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC cysteines and an exchangeable S-adenosyl-L-methionine.
CC {ECO:0000255|HAMAP-Rule:MF_01251};
CC -!- SIMILARITY: Belongs to the UPF0313 family. {ECO:0000255|HAMAP-
CC Rule:MF_01251}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN44538.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP18350.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN44538.2; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP18350.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000095159.1; NZ_WPGW01000034.1.
DR AlphaFoldDB; Q83JL2; -.
DR STRING; 198214.SF3060; -.
DR EnsemblBacteria; AAN44538; AAN44538; SF3060.
DR EnsemblBacteria; AAP18350; AAP18350; S3263.
DR KEGG; sft:NCTC1_03313; -.
DR KEGG; sfx:S3263; -.
DR PATRIC; fig|623.158.peg.3348; -.
DR HOGENOM; CLU_018288_1_1_6; -.
DR OrthoDB; 229299at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.30.20; -; 1.
DR HAMAP; MF_01251; UPF0313; 1.
DR InterPro; IPR006638; Elp3/MiaB/NifB.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR InterPro; IPR022946; UPF0313.
DR InterPro; IPR024560; UPF0313_C.
DR InterPro; IPR013704; UPF0313_N.
DR PANTHER; PTHR32331; PTHR32331; 1.
DR Pfam; PF11842; DUF3362; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF08497; Radical_SAM_N; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01069; UPF0313; 1.
DR SMART; SM00729; Elp3; 1.
DR TIGRFAMs; TIGR03904; SAM_YgiQ; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW S-adenosyl-L-methionine.
FT CHAIN 1..739
FT /note="UPF0313 protein YgiQ"
FT /id="PRO_0000076396"
FT DOMAIN 372..650
FT /note="Radical SAM core"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT REGION 685..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 386
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT BINDING 390
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
FT BINDING 393
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_note="4Fe-4S-S-AdoMet"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01251"
SQ SEQUENCE 739 AA; 83493 MW; 517E26AFB226F410 CRC64;
MSSISLIQPD RDLFSWPQYW AACFGPAPFL PMSREEMDQL GWDSCDIILV TGDAYVDHPS
FGMAICGRML EAQGFRVGII AQPDWSSKDD FMRLGKPNLF FGVTAGNMDS MINRYTADRR
LRHDDAYTPD NVAGKRPDRA TLVYTQRCKE AWKDVPVILG GIEASLRRTA HYDYWSDTVR
RSVLVDSKAD MLMFGNGERP LVEVAHRLAM GEPISEIRDV RNTAIIVKEA LPGWSGVDST
RLDTLGKIDP IPHPYGEDLP CADNKPVAPK KQEAKAVIVQ PPRQKPWEKT YVLLPSFEKV
KGDKVLYAHA SRILHHETNP GCARALMQKH GDRYVWINPP AIPLSTEEMD SVFALPYKRV
PHPAYGNARI PAYEMIRFSV NIMRGCFGGC SFCSITEHEG RIIQSRSEDS IINEIEAIRD
TVPGFTGVIS DLGGPTANMY MLRCKSPRAE QTCRRLSCVY PDICPHMDTN HEPTINLYRR
ARDLKGIKKI LIASGVRYDI AVEDPRYIKE LATHHVGGYL KIAPEHTEEG PLSKMMKPGM
GSYDRFKELF DTYSKQAGKE QYLIPYFISA HPGTRDEDMV NLALWLKKHR FRLDQVQNFY
PSPLANSTTM YYTGKKPLAK IGYKSEGVFV PKGDKQRRLH KALLRYHDPA NWPLIRQALE
AMGKKHLIGS RRDCLVPAPT IEEMREARRQ NRNTRPALTK HTPMATQRQT PATAKKASST
QSRPVNAGAK KRPKAAVGR
