YGN3_SCHPO
ID YGN3_SCHPO Reviewed; 157 AA.
AC O74797;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=UPF0587 protein C2D10.03c;
GN Name=Ess1 {ECO:0000303|PubMed:30280012}; ORFNames=SPBC2D10.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=30280012; DOI=10.7717/peerj.5377;
RA Rahaman S.N., Mat Yusop J., Mohamed-Hussein Z.A., Aizat W.M., Ho K.L.,
RA Teh A.H., Waterman J., Tan B.K., Tan H.L., Li A.Y., Chen E.S., Ng C.L.;
RT "Crystal structure and functional analysis of human C1ORF123.";
RL PeerJ 6:E5377-E5377(2018).
CC -!- DOMAIN: Requires a bound zinc ion for normal folding and solubility.
CC {ECO:0000250|UniProtKB:Q9NWV4}.
CC -!- DISRUPTION PHENOTYPE: No obvious growth defects. No increased
CC sensitivity to oxidative stress caused by exposure to hydrogen peroxide
CC (in vitro). {ECO:0000269|PubMed:30280012}.
CC -!- SIMILARITY: Belongs to the UPF0587 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21161.1; -; Genomic_DNA.
DR PIR; T40106; T40106.
DR RefSeq; NP_001018829.2; NM_001022142.3.
DR AlphaFoldDB; O74797; -.
DR SMR; O74797; -.
DR BioGRID; 280392; 9.
DR STRING; 4896.SPBC2D10.03c.1; -.
DR MaxQB; O74797; -.
DR PaxDb; O74797; -.
DR EnsemblFungi; SPBC2D10.03c.1; SPBC2D10.03c.1:pep; SPBC2D10.03c.
DR GeneID; 3361316; -.
DR KEGG; spo:SPBC2D10.03c; -.
DR PomBase; SPBC2D10.03c; -.
DR VEuPathDB; FungiDB:SPBC2D10.03c; -.
DR eggNOG; KOG1296; Eukaryota.
DR HOGENOM; CLU_114688_0_0_1; -.
DR InParanoid; O74797; -.
DR OMA; FFMKCKM; -.
DR PhylomeDB; O74797; -.
DR PRO; PR:O74797; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR InterPro; IPR008584; CXXC_Zn-binding_euk.
DR PANTHER; PTHR12857; PTHR12857; 1.
DR Pfam; PF05907; DUF866; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..157
FT /note="UPF0587 protein C2D10.03c"
FT /id="PRO_0000338391"
FT BINDING 34
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 37
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 68
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
SQ SEQUENCE 157 AA; 17663 MW; 7603F6BCAFDCED44 CRC64;
MGKFALNLNA ELTGVKNLAP KDEESFYYAF KVQCSGCREI HDNAIEISRS ETHSIPGSKG
EANLIWTCKN CRKTCSFVIE GPFSPYNDSQ ETKKVLVLEC RGCELVEFIP QGEWIANGAE
SNTLFDEIVL EDDWYDYDEN ASSEVSITNL EWSISKA