YGV8_SCHPO
ID YGV8_SCHPO Reviewed; 865 AA.
AC O43022;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Uncharacterized protein C354.08c;
GN ORFNames=SPBC354.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Acts as an osmosensitive calcium-permeable cation channel.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Note=Localizes to the cell tip and the barrier
CC septum.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family. {ECO:0000305}.
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DR EMBL; CU329671; CAA17808.1; -; Genomic_DNA.
DR PIR; T40288; T40288.
DR RefSeq; NP_595232.1; NM_001021138.2.
DR AlphaFoldDB; O43022; -.
DR SMR; O43022; -.
DR BioGRID; 277504; 5.
DR STRING; 4896.SPBC354.08c.1; -.
DR iPTMnet; O43022; -.
DR MaxQB; O43022; -.
DR PaxDb; O43022; -.
DR PRIDE; O43022; -.
DR EnsemblFungi; SPBC354.08c.1; SPBC354.08c.1:pep; SPBC354.08c.
DR GeneID; 2540988; -.
DR KEGG; spo:SPBC354.08c; -.
DR PomBase; SPBC354.08c; -.
DR VEuPathDB; FungiDB:SPBC354.08c; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_1_0_1; -.
DR InParanoid; O43022; -.
DR OMA; SAYKPPW; -.
DR PhylomeDB; O43022; -.
DR PRO; PR:O43022; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium activated cation channel activity; IBA:GO_Central.
DR GO; GO:0015085; F:calcium ion transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0070588; P:calcium ion transmembrane transport; ISS:PomBase.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR032880; Csc1_N.
DR InterPro; IPR027815; PHM7_cyt.
DR InterPro; IPR003864; RSN1_7TM.
DR PANTHER; PTHR13018; PTHR13018; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium; Cell membrane; Glycoprotein; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..865
FT /note="Uncharacterized protein C354.08c"
FT /id="PRO_0000315636"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..151
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..420
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..470
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 492..511
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 533..582
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 583..603
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 604..640
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 662..665
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 687..865
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 802
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 853
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 865 AA; 99207 MW; 9F7BD97B43FB1904 CRC64;
MVIEKRESFI EVVINSLLND NPAQAKFDKY SILVSLGFSS LLSVILLCIF TLLRTKFNTY
DRCIPPMKKS LWGWIEPLWS IKVEDCLYNM GADAVISLLF SRFCRDVFLI LAAICCTILI
PINIVATNKT LANSDSQNAY AKLSIQNVTG NWTWAHVVIC YVFNVLVLFL LARYYQIVMR
IRQRYYRSPT YQQSMSSRSL LIMDIPTTMR SNNGLSILAS RLKSSEAPMH VHICHAIKNL
PKILKKHDNA VRSLEAVLAK FFKNPKKLPD DRPVRRVKQG LLTSEKVDAI DYYSAKIENY
GLRVDAARES LYENEFEHYG FITYKSSYIA HDTARHNSRV AGASVSMAPE PSDFLWDNLS
LAWSTRLFNR MIGNILFIIL IIAWIIETAL VAIFISNLYH LGSVWPWLQQ QLTSRSGFWS
IVQGILSPAV AGFTFMILEI IMRRISYWQG SFTKSSRERG VLNKLHIIFT LDNFIIYTLM
AVFWRLGVII AYKTKEEGNF AEGMSAFATF DTVGLSVSSF VQFSTFWIMF IAHSTCSFFV
EIAQPITLTI RLIKTKFFSP TPRDLLEWTA PTKYVYSQVL NKLIYFFTIA ICYACINPLV
LLFASVLFCV NYLTQKYILM YVSNSSTESG GGYWRPVVNR ILLGLELANI ILFLCLWVQG
GRVRAYCIIP NFSFAIAFKI WCMFALDPKS HYMIEDPYMK VVEPLENEIS ESEMCFGHPS
TYAPLLVPMV RSDARALLPL FYSGRTETHN KFDFATDSDD ASEKHLRGEE EPLENVDFVD
IDNVDTAKEV HDQQQVQQLK KNLSRSYTRS RGVSLRARLN EEELPLTESI TQDSQISIPE
TLESQSTEIT PINVSEHYDK YYHIF
