YGV9_SCHPO
ID YGV9_SCHPO Reviewed; 794 AA.
AC O43023;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Inactive zinc metalloprotease C354.09c;
GN ORFNames=SPBC354.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Although related to the peptidase M28 family, it lacks the
CC conserved zinc-binding and active sites and therefore has probably lost
CC hydrolase activity. {ECO:0000305}.
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DR EMBL; CU329671; CAA17809.1; -; Genomic_DNA.
DR PIR; T40289; T40289.
DR RefSeq; NP_595233.1; NM_001021139.2.
DR AlphaFoldDB; O43023; -.
DR SMR; O43023; -.
DR BioGRID; 277468; 21.
DR STRING; 4896.SPBC354.09c.1; -.
DR MaxQB; O43023; -.
DR PaxDb; O43023; -.
DR EnsemblFungi; SPBC354.09c.1; SPBC354.09c.1:pep; SPBC354.09c.
DR GeneID; 2540952; -.
DR KEGG; spo:SPBC354.09c; -.
DR PomBase; SPBC354.09c; -.
DR VEuPathDB; FungiDB:SPBC354.09c; -.
DR eggNOG; KOG2195; Eukaryota.
DR HOGENOM; CLU_005688_2_1_1; -.
DR InParanoid; O43023; -.
DR OMA; HEGWESA; -.
DR PhylomeDB; O43023; -.
DR Reactome; R-SPO-8963693; Aspartate and asparagine metabolism.
DR Reactome; R-SPO-8980692; RHOA GTPase cycle.
DR Reactome; R-SPO-9013026; RHOB GTPase cycle.
DR Reactome; R-SPO-9013106; RHOC GTPase cycle.
DR Reactome; R-SPO-9696273; RND1 GTPase cycle.
DR PRO; PR:O43023; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0071627; C:integral component of fungal-type vacuolar membrane; IC:PomBase.
DR GO; GO:0004180; F:carboxypeptidase activity; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISO:PomBase.
DR Gene3D; 1.20.930.40; -; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404; PTHR10404; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF47672; SSF47672; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..794
FT /note="Inactive zinc metalloprotease C354.09c"
FT /id="PRO_0000174141"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 88966 MW; FB998B33E33B8B9D CRC64;
MTDEKHVYVP PPKDPPSYEE VALHSALNNS APPNDGEQNE TSMEEMEIIE PPSEDSSRFP
LLRTKLAAIH EGWESACHSF EIRFASTFHR IPFQFLYLAV IATVIILASY YGYFDGVPAW
RSVHHYGEDV LLNYIKGCDI SDTRQQVMTL SSIPHLAGTV GDSSLLQMIM NRLYYEKGTI
VDFREFYAYL NFPQLVSLSI DGDDSFHPSL IESYQVGGYD GVSIPTPATF GGSPSGFVNA
PLVYANRGRI EDFEWLVNSG IYVESSIVLV RANQSDFALA TANAEKYNAS AILIFEDTYL
TSLDNLNQVY PAGPYPSANS LYRGSVANHY YYVGDPLTPG WSAHEETNRI SPKDANVLPS
IVSIPITFND GIELLKRLQG HGHLVKDSNW CQDLAPVLSE VWTGSKISSP GLEVNVLQDI
EDKQKIINIM AQIDGYESDQ ILVVGAPRDS WCTGASDSSV GTSLLIDVIS TFANMAQDLS
WKPRRTIVFA SWDARQFNAI GSTEFLEYWK ESLEAKAVAY INVDVAVSGD TFTARTVPGL
KKVIQRAFDV ANEEDEMKAA NIITDDFDYT SDLTSFLTFA GIPVVNLAFE RNEENPTPMP
FLGSCEDTVS WIDTFGSEYW ENAARLGKIW SYLILFLAND PVVPYDLEDE INGVGEMLKR
IPEIPGANAL DLRKINEEFS ELLESLIRFE DEIREWKSLM MHNSYTVSVK KHPELEGYNA
KLARFERSFL DEAGLPGHEW YKHLIYGPNL RNSHSQLFPS IFDALLYGDV EAAQKEVKRI
ALALDRAHNE IRFA
