YH006_HUMAN
ID YH006_HUMAN Reviewed; 208 AA.
AC Q71RG6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Putative chemokine-related protein FP248;
DE AltName: Full=Protein N73;
DE Flags: Precursor;
GN ORFNames=FP248;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=22586462; DOI=10.1371/journal.pone.0036151;
RA Tomczak A., Sontheimer J., Drechsel D., Hausdorf R., Gentzel M.,
RA Shevchenko A., Eichler S., Fahmy K., Buchholz F., Pisabarro M.T.;
RT "3D profile-based approach to proteome-wide discovery of novel human
RT chemokines.";
RL PLoS ONE 7:E36151-E36151(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- CAUTION: Product of a dubious gene prediction. Identified as a novel
CC protein related to chemokines on the basis of a 3D profile-based
CC proteome-wide analysis (PubMed:22586462).
CC {ECO:0000305|PubMed:22586462}.
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DR EMBL; AF370371; AAQ15207.1; -; mRNA.
DR EMBL; AC100803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q71RG6; -.
DR GlyGen; Q71RG6; 1 site.
DR BioMuta; FP248; -.
DR PRIDE; Q71RG6; -.
DR neXtProt; NX_Q71RG6; -.
DR InParanoid; Q71RG6; -.
DR Pharos; Q71RG6; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q71RG6; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 5: Uncertain;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..208
FT /note="Putative chemokine-related protein FP248"
FT /id="PRO_0000332262"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 208 AA; 21376 MW; 82170683D21915BE CRC64;
MGTGGSLLCG CSLVLSCLCP SASLPDPGNS TWPPGAQAGL PAALALPLPR LPRILFPMAG
RPARPSSDFV GCAQGMCCHG RQGTVHIHTS SVSCWTPCPV TGTGGTAVSR KDRVLPHRRQ
VSLACVCAVG ERAGQLWSQK PVQMARPSAR HLLPRGSSPN SQAVLLPSVC PVPWPPVGPS
PGQGEGLSPA FPGVGTDRGD SWALVLQV